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Adaptive bi-level programming for optimal gene knockouts for targeted overproduction under phenotypic constraints

BACKGROUND: Optimization procedures to identify gene knockouts for targeted biochemical overproduction have been widely in use in modern metabolic engineering. Flux balance analysis (FBA) framework has provided conceptual simplifications for genome-scale dynamic analysis at steady states. Based on F...

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Detalles Bibliográficos
Autores principales:	Ren, Shaogang, Zeng, Bo, Qian, Xiaoning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549844/ https://www.ncbi.nlm.nih.gov/pubmed/23368729 http://dx.doi.org/10.1186/1471-2105-14-S2-S17

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