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A noncatalytic function of the ligation complex during nonhomologous end joining

Nonhomologous end joining is the primary deoxyribonucleic acid (DNA) double-strand break repair pathway in multicellular eukaryotes. To initiate repair, Ku binds DNA ends and recruits the DNA-dependent protein kinase (DNA-PK) catalytic subunit (DNA-PKcs) forming the holoenzyme. Early end synapsis is...

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Detalles Bibliográficos
Autores principales:	Cottarel, Jessica, Frit, Philippe, Bombarde, Oriane, Salles, Bernard, Négrel, Aurélie, Bernard, Stéphanie, Jeggo, Penny A., Lieber, Michael R., Modesti, Mauro, Calsou, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549972/ https://www.ncbi.nlm.nih.gov/pubmed/23337116 http://dx.doi.org/10.1083/jcb.201203128

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