Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

OBJECTIVE: Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This study examines the role of an abundant extracellular matrix component, the megadalton glycosaminoglycan hyaluronan (HA), as a novel therapeu...

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Detalles Bibliográficos
Autores principales: Jacobetz, Michael A, Chan, Derek S, Neesse, Albrecht, Bapiro, Tashinga E, Cook, Natalie, Frese, Kristopher K, Feig, Christine, Nakagawa, Tomoaki, Caldwell, Meredith E, Zecchini, Heather I, Lolkema, Martijn P, Jiang, Ping, Kultti, Anne, Thompson, Curtis B, Maneval, Daniel C, Jodrell, Duncan I, Frost, Gregory I, Shepard, H M, Skepper, Jeremy N, Tuveson, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Group 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551211/
https://www.ncbi.nlm.nih.gov/pubmed/22466618
http://dx.doi.org/10.1136/gutjnl-2012-302529

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