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A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

OBJECTIVE: Wnt signalling is critical for normal intestinal development and homeostasis. Wnt dysregulation occurs in almost all human and murine intestinal tumours and an optimal but not excessive level of Wnt activation is considered favourable for tumourigenesis. The authors assessed effects of pa...

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Detalles Bibliográficos
Autores principales:	Leedham, Simon J, Rodenas-Cuadrado, Pedro, Howarth, Kimberley, Lewis, Annabelle, Mallappa, Sreelakshmi, Segditsas, Stefania, Davis, Hayley, Jeffery, Rosemary, Rodriguez-Justo, Manuel, Keshav, Satish, Travis, Simon P L, Graham, Trevor A, East, James, Clark, Susan, Tomlinson, Ian P M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Group 2013
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551213/ https://www.ncbi.nlm.nih.gov/pubmed/22287596 http://dx.doi.org/10.1136/gutjnl-2011-301601

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