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Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab

Treatment of a relapsed glioma is a clinical challenge nowadays. New active treatments are required to treat these difficult diseases. Here we present a durable complete remission of a relapsed glioblastoma that has achieved a complete radiologic response with the combination of cetuximab and bevaci...

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Autores principales: Blesa, Joan Manel Gasent, Mollá, Sara Blasco, Esparcia, María Fonfría, Ortells, José Miguel Sempere, Godoy, Miguel Peris, Das, Adrian Munilla, Magan, Balbino Mancheño, Pulla, Mariano Provencio, Sanchez, Jose Luis, Canales, Juan Bautista Laforga, Candel, Vicente Alberola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551399/
https://www.ncbi.nlm.nih.gov/pubmed/23341811
http://dx.doi.org/10.1159/000341852
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author Blesa, Joan Manel Gasent
Mollá, Sara Blasco
Esparcia, María Fonfría
Ortells, José Miguel Sempere
Godoy, Miguel Peris
Das, Adrian Munilla
Magan, Balbino Mancheño
Pulla, Mariano Provencio
Sanchez, Jose Luis
Canales, Juan Bautista Laforga
Candel, Vicente Alberola
author_facet Blesa, Joan Manel Gasent
Mollá, Sara Blasco
Esparcia, María Fonfría
Ortells, José Miguel Sempere
Godoy, Miguel Peris
Das, Adrian Munilla
Magan, Balbino Mancheño
Pulla, Mariano Provencio
Sanchez, Jose Luis
Canales, Juan Bautista Laforga
Candel, Vicente Alberola
author_sort Blesa, Joan Manel Gasent
collection PubMed
description Treatment of a relapsed glioma is a clinical challenge nowadays. New active treatments are required to treat these difficult diseases. Here we present a durable complete remission of a relapsed glioblastoma that has achieved a complete radiologic response with the combination of cetuximab and bevacizumab, in a third-line setting, that has offered a progression-free survival of 20 months. We consider here both potential mechanisms for the explanation of this result. First, the potential target of the cancer stem cells (CSCs) with these two antibodies, and second, the potential recruitment of the immune system to directly pursue the CSCs.
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spelling pubmed-35513992013-01-22 Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab Blesa, Joan Manel Gasent Mollá, Sara Blasco Esparcia, María Fonfría Ortells, José Miguel Sempere Godoy, Miguel Peris Das, Adrian Munilla Magan, Balbino Mancheño Pulla, Mariano Provencio Sanchez, Jose Luis Canales, Juan Bautista Laforga Candel, Vicente Alberola Case Rep Oncol Published online: December, 2012 Treatment of a relapsed glioma is a clinical challenge nowadays. New active treatments are required to treat these difficult diseases. Here we present a durable complete remission of a relapsed glioblastoma that has achieved a complete radiologic response with the combination of cetuximab and bevacizumab, in a third-line setting, that has offered a progression-free survival of 20 months. We consider here both potential mechanisms for the explanation of this result. First, the potential target of the cancer stem cells (CSCs) with these two antibodies, and second, the potential recruitment of the immune system to directly pursue the CSCs. S. Karger AG 2012-12-20 /pmc/articles/PMC3551399/ /pubmed/23341811 http://dx.doi.org/10.1159/000341852 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: December, 2012
Blesa, Joan Manel Gasent
Mollá, Sara Blasco
Esparcia, María Fonfría
Ortells, José Miguel Sempere
Godoy, Miguel Peris
Das, Adrian Munilla
Magan, Balbino Mancheño
Pulla, Mariano Provencio
Sanchez, Jose Luis
Canales, Juan Bautista Laforga
Candel, Vicente Alberola
Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab
title Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab
title_full Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab
title_fullStr Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab
title_full_unstemmed Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab
title_short Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab
title_sort durable complete remission of a brainstem glioma treated with a combination of bevacizumab and cetuximab
topic Published online: December, 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551399/
https://www.ncbi.nlm.nih.gov/pubmed/23341811
http://dx.doi.org/10.1159/000341852
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