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Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab
Treatment of a relapsed glioma is a clinical challenge nowadays. New active treatments are required to treat these difficult diseases. Here we present a durable complete remission of a relapsed glioblastoma that has achieved a complete radiologic response with the combination of cetuximab and bevaci...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551399/ https://www.ncbi.nlm.nih.gov/pubmed/23341811 http://dx.doi.org/10.1159/000341852 |
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author | Blesa, Joan Manel Gasent Mollá, Sara Blasco Esparcia, María Fonfría Ortells, José Miguel Sempere Godoy, Miguel Peris Das, Adrian Munilla Magan, Balbino Mancheño Pulla, Mariano Provencio Sanchez, Jose Luis Canales, Juan Bautista Laforga Candel, Vicente Alberola |
author_facet | Blesa, Joan Manel Gasent Mollá, Sara Blasco Esparcia, María Fonfría Ortells, José Miguel Sempere Godoy, Miguel Peris Das, Adrian Munilla Magan, Balbino Mancheño Pulla, Mariano Provencio Sanchez, Jose Luis Canales, Juan Bautista Laforga Candel, Vicente Alberola |
author_sort | Blesa, Joan Manel Gasent |
collection | PubMed |
description | Treatment of a relapsed glioma is a clinical challenge nowadays. New active treatments are required to treat these difficult diseases. Here we present a durable complete remission of a relapsed glioblastoma that has achieved a complete radiologic response with the combination of cetuximab and bevacizumab, in a third-line setting, that has offered a progression-free survival of 20 months. We consider here both potential mechanisms for the explanation of this result. First, the potential target of the cancer stem cells (CSCs) with these two antibodies, and second, the potential recruitment of the immune system to directly pursue the CSCs. |
format | Online Article Text |
id | pubmed-3551399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-35513992013-01-22 Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab Blesa, Joan Manel Gasent Mollá, Sara Blasco Esparcia, María Fonfría Ortells, José Miguel Sempere Godoy, Miguel Peris Das, Adrian Munilla Magan, Balbino Mancheño Pulla, Mariano Provencio Sanchez, Jose Luis Canales, Juan Bautista Laforga Candel, Vicente Alberola Case Rep Oncol Published online: December, 2012 Treatment of a relapsed glioma is a clinical challenge nowadays. New active treatments are required to treat these difficult diseases. Here we present a durable complete remission of a relapsed glioblastoma that has achieved a complete radiologic response with the combination of cetuximab and bevacizumab, in a third-line setting, that has offered a progression-free survival of 20 months. We consider here both potential mechanisms for the explanation of this result. First, the potential target of the cancer stem cells (CSCs) with these two antibodies, and second, the potential recruitment of the immune system to directly pursue the CSCs. S. Karger AG 2012-12-20 /pmc/articles/PMC3551399/ /pubmed/23341811 http://dx.doi.org/10.1159/000341852 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published online: December, 2012 Blesa, Joan Manel Gasent Mollá, Sara Blasco Esparcia, María Fonfría Ortells, José Miguel Sempere Godoy, Miguel Peris Das, Adrian Munilla Magan, Balbino Mancheño Pulla, Mariano Provencio Sanchez, Jose Luis Canales, Juan Bautista Laforga Candel, Vicente Alberola Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab |
title | Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab |
title_full | Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab |
title_fullStr | Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab |
title_full_unstemmed | Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab |
title_short | Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab |
title_sort | durable complete remission of a brainstem glioma treated with a combination of bevacizumab and cetuximab |
topic | Published online: December, 2012 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551399/ https://www.ncbi.nlm.nih.gov/pubmed/23341811 http://dx.doi.org/10.1159/000341852 |
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