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Conformation-Dependent Oligomers in Cerebrospinal Fluid of Presymptomatic Familial Alzheimer's Disease Mutation Carriers

BACKGROUND/AIMS: Oligomerization of amyloid beta (Aβ) is a hypothesized step in the formation of plaques in Alzheimer's disease (AD) but has been difficult to demonstrate in vivo in humans. As persons destined to develop familial AD (FAD) due to fully penetrant autosomal dominant mutations are...

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Detalles Bibliográficos
Autores principales:	Ringman, John M., Tomic, Jennifer L., Coppola, Giovanni, Elashoff, David, Gylys, Karen H., Glabe, Charles G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	S. Karger AG 2012
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551434/ https://www.ncbi.nlm.nih.gov/pubmed/23341831 http://dx.doi.org/10.1159/000345771

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