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Angiosarcoma Involving Solid Organs and the Gastrointestinal Tract with Life-Threatening Bleeding
We report a rare case of angiosarcoma involving the gastrointestinal tract, liver, spleen, pancreas, kidney, lung and vertebrae, as well as bulky dissemination in the pleuroperitoneal membranes. A 72-year-old man with no history of illness became aware of melena. Laboratory findings revealed anemia,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551437/ https://www.ncbi.nlm.nih.gov/pubmed/23341800 http://dx.doi.org/10.1159/000346398 |
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author | Maeyashiki, Chiaki Nagata, Naoyoshi Uemura, Naomi |
author_facet | Maeyashiki, Chiaki Nagata, Naoyoshi Uemura, Naomi |
author_sort | Maeyashiki, Chiaki |
collection | PubMed |
description | We report a rare case of angiosarcoma involving the gastrointestinal tract, liver, spleen, pancreas, kidney, lung and vertebrae, as well as bulky dissemination in the pleuroperitoneal membranes. A 72-year-old man with no history of illness became aware of melena. Laboratory findings revealed anemia, and upper gastrointestinal endoscopy revealed multiple reddish nodules in the stomach and duodenum. However, biopsy specimens showed no evidence of histological features. Computed tomography and fluorodeoxyglucose positron emission tomography showed space-occupying lesions in the spleen, liver and vertebrae. Angiosarcoma was diagnosed by endoscopic ultrasound and fine needle aspiration biopsy of the spleen and repeated endoscopic biopsy of the stomach. We performed laparoscopic splenectomy to avoid rupture of the involved spleen. Due to continuous gastrointestinal bleeding, double balloon endoscopy was performed and multiple bleeding lesions were detected throughout the small intestine. Surgical hemostasis was performed by partial enterectomy, but anemia continued to worsen. Therefore, we conducted transcatheter arterial embolization. Despite attempting several modalities and frequent daily blood transfusion, the anemia did not improve, and the patient expired due to hemorrhagic shock. Subsequent autopsy revealed the cause of death as rupture and bleeding due to disseminated involvement of the small intestine. |
format | Online Article Text |
id | pubmed-3551437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-35514372013-01-22 Angiosarcoma Involving Solid Organs and the Gastrointestinal Tract with Life-Threatening Bleeding Maeyashiki, Chiaki Nagata, Naoyoshi Uemura, Naomi Case Rep Gastroenterol Published online: December, 2012 We report a rare case of angiosarcoma involving the gastrointestinal tract, liver, spleen, pancreas, kidney, lung and vertebrae, as well as bulky dissemination in the pleuroperitoneal membranes. A 72-year-old man with no history of illness became aware of melena. Laboratory findings revealed anemia, and upper gastrointestinal endoscopy revealed multiple reddish nodules in the stomach and duodenum. However, biopsy specimens showed no evidence of histological features. Computed tomography and fluorodeoxyglucose positron emission tomography showed space-occupying lesions in the spleen, liver and vertebrae. Angiosarcoma was diagnosed by endoscopic ultrasound and fine needle aspiration biopsy of the spleen and repeated endoscopic biopsy of the stomach. We performed laparoscopic splenectomy to avoid rupture of the involved spleen. Due to continuous gastrointestinal bleeding, double balloon endoscopy was performed and multiple bleeding lesions were detected throughout the small intestine. Surgical hemostasis was performed by partial enterectomy, but anemia continued to worsen. Therefore, we conducted transcatheter arterial embolization. Despite attempting several modalities and frequent daily blood transfusion, the anemia did not improve, and the patient expired due to hemorrhagic shock. Subsequent autopsy revealed the cause of death as rupture and bleeding due to disseminated involvement of the small intestine. S. Karger AG 2012-12-20 /pmc/articles/PMC3551437/ /pubmed/23341800 http://dx.doi.org/10.1159/000346398 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published online: December, 2012 Maeyashiki, Chiaki Nagata, Naoyoshi Uemura, Naomi Angiosarcoma Involving Solid Organs and the Gastrointestinal Tract with Life-Threatening Bleeding |
title | Angiosarcoma Involving Solid Organs and the Gastrointestinal Tract with Life-Threatening Bleeding |
title_full | Angiosarcoma Involving Solid Organs and the Gastrointestinal Tract with Life-Threatening Bleeding |
title_fullStr | Angiosarcoma Involving Solid Organs and the Gastrointestinal Tract with Life-Threatening Bleeding |
title_full_unstemmed | Angiosarcoma Involving Solid Organs and the Gastrointestinal Tract with Life-Threatening Bleeding |
title_short | Angiosarcoma Involving Solid Organs and the Gastrointestinal Tract with Life-Threatening Bleeding |
title_sort | angiosarcoma involving solid organs and the gastrointestinal tract with life-threatening bleeding |
topic | Published online: December, 2012 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551437/ https://www.ncbi.nlm.nih.gov/pubmed/23341800 http://dx.doi.org/10.1159/000346398 |
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