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Higher lung accumulation of intravenously injected organic nanotubes
The size and shape of intravenously injected particles can affect their biodistribution and is of importance for the development of particulated drug carrier systems. In this study, organic nanotubes (ONTs) with a carboxyl group at the surface, a length of approximately 2 μm and outer diameter of 70...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551461/ https://www.ncbi.nlm.nih.gov/pubmed/23345977 http://dx.doi.org/10.2147/IJN.S38462 |
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author | Maitani, Yoshie Nakamura, Yuri Kon, Masao Sanada, Emi Sumiyoshi, Kae Fujine, Natsuki Asakawa, Masumi Kogiso, Masaki Shimizu, Toshimi |
author_facet | Maitani, Yoshie Nakamura, Yuri Kon, Masao Sanada, Emi Sumiyoshi, Kae Fujine, Natsuki Asakawa, Masumi Kogiso, Masaki Shimizu, Toshimi |
author_sort | Maitani, Yoshie |
collection | PubMed |
description | The size and shape of intravenously injected particles can affect their biodistribution and is of importance for the development of particulated drug carrier systems. In this study, organic nanotubes (ONTs) with a carboxyl group at the surface, a length of approximately 2 μm and outer diameter of 70–90 nm, were injected intravenously into tumor-bearing mice. To use ONTs as drug carriers, the biodistribution in selected organs of ONTs postinjection was examined using irinotecan, as an entrapped water-soluble marker inside ONTs, and gadolinium-chelated ONT, as an ONT marker, and compared with that of a 3 μm fluorescently labeled spherical microparticle which was similar size to the length of ONTs. It was found that for irinotecan, its active metabolite and gadolinium-chelated ONTs were highly accumulated in the lung, but to a lower level in the liver and spleen. On the other hand, microparticles deposited less in the lung and more highly in the liver. Moreover, histologic examination showed ONTs distributed more in lung tissues in part, whereas microparticles were present in blood vessels postinjection. These preliminary results support the notion of using negatively charged ONTs as intravascular carriers to maximize accumulation in the lung whilst reducing sequestration by the liver and spleen. This finding suggested that ONTs are potential carriers for lung-targeting drug delivery. |
format | Online Article Text |
id | pubmed-3551461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-35514612013-01-23 Higher lung accumulation of intravenously injected organic nanotubes Maitani, Yoshie Nakamura, Yuri Kon, Masao Sanada, Emi Sumiyoshi, Kae Fujine, Natsuki Asakawa, Masumi Kogiso, Masaki Shimizu, Toshimi Int J Nanomedicine Original Research The size and shape of intravenously injected particles can affect their biodistribution and is of importance for the development of particulated drug carrier systems. In this study, organic nanotubes (ONTs) with a carboxyl group at the surface, a length of approximately 2 μm and outer diameter of 70–90 nm, were injected intravenously into tumor-bearing mice. To use ONTs as drug carriers, the biodistribution in selected organs of ONTs postinjection was examined using irinotecan, as an entrapped water-soluble marker inside ONTs, and gadolinium-chelated ONT, as an ONT marker, and compared with that of a 3 μm fluorescently labeled spherical microparticle which was similar size to the length of ONTs. It was found that for irinotecan, its active metabolite and gadolinium-chelated ONTs were highly accumulated in the lung, but to a lower level in the liver and spleen. On the other hand, microparticles deposited less in the lung and more highly in the liver. Moreover, histologic examination showed ONTs distributed more in lung tissues in part, whereas microparticles were present in blood vessels postinjection. These preliminary results support the notion of using negatively charged ONTs as intravascular carriers to maximize accumulation in the lung whilst reducing sequestration by the liver and spleen. This finding suggested that ONTs are potential carriers for lung-targeting drug delivery. Dove Medical Press 2013 2013-01-18 /pmc/articles/PMC3551461/ /pubmed/23345977 http://dx.doi.org/10.2147/IJN.S38462 Text en © 2013 Maitani et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Maitani, Yoshie Nakamura, Yuri Kon, Masao Sanada, Emi Sumiyoshi, Kae Fujine, Natsuki Asakawa, Masumi Kogiso, Masaki Shimizu, Toshimi Higher lung accumulation of intravenously injected organic nanotubes |
title | Higher lung accumulation of intravenously injected organic nanotubes |
title_full | Higher lung accumulation of intravenously injected organic nanotubes |
title_fullStr | Higher lung accumulation of intravenously injected organic nanotubes |
title_full_unstemmed | Higher lung accumulation of intravenously injected organic nanotubes |
title_short | Higher lung accumulation of intravenously injected organic nanotubes |
title_sort | higher lung accumulation of intravenously injected organic nanotubes |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551461/ https://www.ncbi.nlm.nih.gov/pubmed/23345977 http://dx.doi.org/10.2147/IJN.S38462 |
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