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Higher lung accumulation of intravenously injected organic nanotubes

The size and shape of intravenously injected particles can affect their biodistribution and is of importance for the development of particulated drug carrier systems. In this study, organic nanotubes (ONTs) with a carboxyl group at the surface, a length of approximately 2 μm and outer diameter of 70...

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Autores principales: Maitani, Yoshie, Nakamura, Yuri, Kon, Masao, Sanada, Emi, Sumiyoshi, Kae, Fujine, Natsuki, Asakawa, Masumi, Kogiso, Masaki, Shimizu, Toshimi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551461/
https://www.ncbi.nlm.nih.gov/pubmed/23345977
http://dx.doi.org/10.2147/IJN.S38462
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author Maitani, Yoshie
Nakamura, Yuri
Kon, Masao
Sanada, Emi
Sumiyoshi, Kae
Fujine, Natsuki
Asakawa, Masumi
Kogiso, Masaki
Shimizu, Toshimi
author_facet Maitani, Yoshie
Nakamura, Yuri
Kon, Masao
Sanada, Emi
Sumiyoshi, Kae
Fujine, Natsuki
Asakawa, Masumi
Kogiso, Masaki
Shimizu, Toshimi
author_sort Maitani, Yoshie
collection PubMed
description The size and shape of intravenously injected particles can affect their biodistribution and is of importance for the development of particulated drug carrier systems. In this study, organic nanotubes (ONTs) with a carboxyl group at the surface, a length of approximately 2 μm and outer diameter of 70–90 nm, were injected intravenously into tumor-bearing mice. To use ONTs as drug carriers, the biodistribution in selected organs of ONTs postinjection was examined using irinotecan, as an entrapped water-soluble marker inside ONTs, and gadolinium-chelated ONT, as an ONT marker, and compared with that of a 3 μm fluorescently labeled spherical microparticle which was similar size to the length of ONTs. It was found that for irinotecan, its active metabolite and gadolinium-chelated ONTs were highly accumulated in the lung, but to a lower level in the liver and spleen. On the other hand, microparticles deposited less in the lung and more highly in the liver. Moreover, histologic examination showed ONTs distributed more in lung tissues in part, whereas microparticles were present in blood vessels postinjection. These preliminary results support the notion of using negatively charged ONTs as intravascular carriers to maximize accumulation in the lung whilst reducing sequestration by the liver and spleen. This finding suggested that ONTs are potential carriers for lung-targeting drug delivery.
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spelling pubmed-35514612013-01-23 Higher lung accumulation of intravenously injected organic nanotubes Maitani, Yoshie Nakamura, Yuri Kon, Masao Sanada, Emi Sumiyoshi, Kae Fujine, Natsuki Asakawa, Masumi Kogiso, Masaki Shimizu, Toshimi Int J Nanomedicine Original Research The size and shape of intravenously injected particles can affect their biodistribution and is of importance for the development of particulated drug carrier systems. In this study, organic nanotubes (ONTs) with a carboxyl group at the surface, a length of approximately 2 μm and outer diameter of 70–90 nm, were injected intravenously into tumor-bearing mice. To use ONTs as drug carriers, the biodistribution in selected organs of ONTs postinjection was examined using irinotecan, as an entrapped water-soluble marker inside ONTs, and gadolinium-chelated ONT, as an ONT marker, and compared with that of a 3 μm fluorescently labeled spherical microparticle which was similar size to the length of ONTs. It was found that for irinotecan, its active metabolite and gadolinium-chelated ONTs were highly accumulated in the lung, but to a lower level in the liver and spleen. On the other hand, microparticles deposited less in the lung and more highly in the liver. Moreover, histologic examination showed ONTs distributed more in lung tissues in part, whereas microparticles were present in blood vessels postinjection. These preliminary results support the notion of using negatively charged ONTs as intravascular carriers to maximize accumulation in the lung whilst reducing sequestration by the liver and spleen. This finding suggested that ONTs are potential carriers for lung-targeting drug delivery. Dove Medical Press 2013 2013-01-18 /pmc/articles/PMC3551461/ /pubmed/23345977 http://dx.doi.org/10.2147/IJN.S38462 Text en © 2013 Maitani et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Maitani, Yoshie
Nakamura, Yuri
Kon, Masao
Sanada, Emi
Sumiyoshi, Kae
Fujine, Natsuki
Asakawa, Masumi
Kogiso, Masaki
Shimizu, Toshimi
Higher lung accumulation of intravenously injected organic nanotubes
title Higher lung accumulation of intravenously injected organic nanotubes
title_full Higher lung accumulation of intravenously injected organic nanotubes
title_fullStr Higher lung accumulation of intravenously injected organic nanotubes
title_full_unstemmed Higher lung accumulation of intravenously injected organic nanotubes
title_short Higher lung accumulation of intravenously injected organic nanotubes
title_sort higher lung accumulation of intravenously injected organic nanotubes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551461/
https://www.ncbi.nlm.nih.gov/pubmed/23345977
http://dx.doi.org/10.2147/IJN.S38462
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