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FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

BACKGROUND: FK506 (Tacrolimus) is an important immunosuppressant, produced by industrial biosynthetic processes using various Streptomyces species. Considering the complex structure of FK506, it is reasonable to expect complex regulatory networks controlling its biosynthesis. Regulatory elements, pr...

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Detalles Bibliográficos
Autores principales:	Goranovič, Dušan, Blažič, Marko, Magdevska, Vasilka, Horvat, Jaka, Kuščer, Enej, Polak, Tomaž, Santos-Aberturas, Javier, Martínez-Castro, Miriam, Barreiro, Carlos, Mrak, Peter, Kopitar, Gregor, Kosec, Gregor, Fujs, Štefan, Martín, Juan F, Petković, Hrvoje
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551636/ https://www.ncbi.nlm.nih.gov/pubmed/23083511 http://dx.doi.org/10.1186/1471-2180-12-238

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