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Alpha B-crystallin is a new prognostic marker for laryngeal squamous cell carcinoma
BACKGROUND: Alpha B-crystallin (αB-crystallin) has been suggested to play an important role in the development of solid tumors. However, the association between αB-crystallin expression and clinicopathological characteristics of human laryngeal carcinoma is not well defined. This study aimed to exam...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551651/ https://www.ncbi.nlm.nih.gov/pubmed/23231769 http://dx.doi.org/10.1186/1756-9966-31-101 |
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author | Mao, Yuan Zhang, Da-Wei Lin, Hong Xiong, Lin Liu, Ying Li, Qing-Dong Ma, Jun Cao, Qing Chen, Ren-Jie Zhu, Jin Feng, Zhen-Qing |
author_facet | Mao, Yuan Zhang, Da-Wei Lin, Hong Xiong, Lin Liu, Ying Li, Qing-Dong Ma, Jun Cao, Qing Chen, Ren-Jie Zhu, Jin Feng, Zhen-Qing |
author_sort | Mao, Yuan |
collection | PubMed |
description | BACKGROUND: Alpha B-crystallin (αB-crystallin) has been suggested to play an important role in the development of solid tumors. However, the association between αB-crystallin expression and clinicopathological characteristics of human laryngeal carcinoma is not well defined. This study aimed to examine the expression of αB-crystallin in human laryngeal squamous cell carcinoma (LSCC) and investigate the relationship between its expression and the prognosis of LSCC. METHODS: Real-time polymerase chain reaction (six LSCC samples, six tumor-adjacent normal samples) and immunohistochemistry by tissue microarrays (109 LSCC samples and 28 tumor-adjacent normal samples) were performed to characterize expression of the αB-crystallin gene in LSCC. Kaplan-Meier survival and Cox regression analyses were carried out to evaluate the prognosis of LSCC. RESULTS: Real-time polymerase chain reaction and immunohistochemistry analysis showed that the expression of αB-crystallin in LSCC was significantly higher than that in tumor-adjacent normal tissues. Moreover, the expression level of αB-crystallin protein in LSCC was significantly related to alcohol consumption (P = 0.022), tumor differentiation (P = 0.007), pTNM stage (P = 0.041) and 5 years’ survival (P =0.030). COX multi-factor analysis showed that αB-crystallin (P = 0.013), as well as pTNM stage (P =0.027) and lymphatic metastasis (P = 0.015) were independent prognosis factors for LSCC. CONCLUSIONS: The data suggest that αB-crystallin expression is correlated with malignant phenotypes of LSCC and it may serve as a novel prognostic factor for LSCC. |
format | Online Article Text |
id | pubmed-3551651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35516512013-01-24 Alpha B-crystallin is a new prognostic marker for laryngeal squamous cell carcinoma Mao, Yuan Zhang, Da-Wei Lin, Hong Xiong, Lin Liu, Ying Li, Qing-Dong Ma, Jun Cao, Qing Chen, Ren-Jie Zhu, Jin Feng, Zhen-Qing J Exp Clin Cancer Res Research BACKGROUND: Alpha B-crystallin (αB-crystallin) has been suggested to play an important role in the development of solid tumors. However, the association between αB-crystallin expression and clinicopathological characteristics of human laryngeal carcinoma is not well defined. This study aimed to examine the expression of αB-crystallin in human laryngeal squamous cell carcinoma (LSCC) and investigate the relationship between its expression and the prognosis of LSCC. METHODS: Real-time polymerase chain reaction (six LSCC samples, six tumor-adjacent normal samples) and immunohistochemistry by tissue microarrays (109 LSCC samples and 28 tumor-adjacent normal samples) were performed to characterize expression of the αB-crystallin gene in LSCC. Kaplan-Meier survival and Cox regression analyses were carried out to evaluate the prognosis of LSCC. RESULTS: Real-time polymerase chain reaction and immunohistochemistry analysis showed that the expression of αB-crystallin in LSCC was significantly higher than that in tumor-adjacent normal tissues. Moreover, the expression level of αB-crystallin protein in LSCC was significantly related to alcohol consumption (P = 0.022), tumor differentiation (P = 0.007), pTNM stage (P = 0.041) and 5 years’ survival (P =0.030). COX multi-factor analysis showed that αB-crystallin (P = 0.013), as well as pTNM stage (P =0.027) and lymphatic metastasis (P = 0.015) were independent prognosis factors for LSCC. CONCLUSIONS: The data suggest that αB-crystallin expression is correlated with malignant phenotypes of LSCC and it may serve as a novel prognostic factor for LSCC. BioMed Central 2012-12-12 /pmc/articles/PMC3551651/ /pubmed/23231769 http://dx.doi.org/10.1186/1756-9966-31-101 Text en Copyright ©2012 Mao et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Mao, Yuan Zhang, Da-Wei Lin, Hong Xiong, Lin Liu, Ying Li, Qing-Dong Ma, Jun Cao, Qing Chen, Ren-Jie Zhu, Jin Feng, Zhen-Qing Alpha B-crystallin is a new prognostic marker for laryngeal squamous cell carcinoma |
title | Alpha B-crystallin is a new prognostic marker for laryngeal squamous cell carcinoma |
title_full | Alpha B-crystallin is a new prognostic marker for laryngeal squamous cell carcinoma |
title_fullStr | Alpha B-crystallin is a new prognostic marker for laryngeal squamous cell carcinoma |
title_full_unstemmed | Alpha B-crystallin is a new prognostic marker for laryngeal squamous cell carcinoma |
title_short | Alpha B-crystallin is a new prognostic marker for laryngeal squamous cell carcinoma |
title_sort | alpha b-crystallin is a new prognostic marker for laryngeal squamous cell carcinoma |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551651/ https://www.ncbi.nlm.nih.gov/pubmed/23231769 http://dx.doi.org/10.1186/1756-9966-31-101 |
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