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Multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite Plasmodium yoelii

BACKGROUND: Malaria is the most significant human parasitic disease, and yet understanding of the energy metabolism of the principle pathogen, Plasmodium falciparum, remains to be fully elucidated. Amino acids were shown to be essential nutritional requirements since early times and much of the curr...

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Autores principales: Saiki, Erisha, Nagao, Kenji, Aonuma, Hiroka, Fukumoto, Shinya, Xuan, Xuenan, Bannai, Makoto, Kanuka, Hirotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551679/
https://www.ncbi.nlm.nih.gov/pubmed/23324562
http://dx.doi.org/10.1186/1475-2875-12-19
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author Saiki, Erisha
Nagao, Kenji
Aonuma, Hiroka
Fukumoto, Shinya
Xuan, Xuenan
Bannai, Makoto
Kanuka, Hirotaka
author_facet Saiki, Erisha
Nagao, Kenji
Aonuma, Hiroka
Fukumoto, Shinya
Xuan, Xuenan
Bannai, Makoto
Kanuka, Hirotaka
author_sort Saiki, Erisha
collection PubMed
description BACKGROUND: Malaria is the most significant human parasitic disease, and yet understanding of the energy metabolism of the principle pathogen, Plasmodium falciparum, remains to be fully elucidated. Amino acids were shown to be essential nutritional requirements since early times and much of the current knowledge of Plasmodium energy metabolism is based on early biochemical work, performed using basic analytical techniques, carried out almost exclusively on human plasma with considerable inter-individual variability. METHODS: In order to further characterize the fate of amino acid metabolism in malaria parasite, multivariate analysis using statistical modelling of amino acid concentrations (aminogram) of plasma and liver were determined in host infected with rodent malaria parasite, Plasmodium yoelii. RESULTS AND CONCLUSION: Comprehensive and statistical aminogram analysis revealed that P. yoelii infection caused drastic change of plasma and liver aminogram, and altered intra- and inter-correlation of amino acid concentration in plasma and liver. These findings of the interactions between amino acids and Plasmodium infection may provide insight to reveal the interaction between nutrients and parasites.
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spelling pubmed-35516792013-01-24 Multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite Plasmodium yoelii Saiki, Erisha Nagao, Kenji Aonuma, Hiroka Fukumoto, Shinya Xuan, Xuenan Bannai, Makoto Kanuka, Hirotaka Malar J Methodology BACKGROUND: Malaria is the most significant human parasitic disease, and yet understanding of the energy metabolism of the principle pathogen, Plasmodium falciparum, remains to be fully elucidated. Amino acids were shown to be essential nutritional requirements since early times and much of the current knowledge of Plasmodium energy metabolism is based on early biochemical work, performed using basic analytical techniques, carried out almost exclusively on human plasma with considerable inter-individual variability. METHODS: In order to further characterize the fate of amino acid metabolism in malaria parasite, multivariate analysis using statistical modelling of amino acid concentrations (aminogram) of plasma and liver were determined in host infected with rodent malaria parasite, Plasmodium yoelii. RESULTS AND CONCLUSION: Comprehensive and statistical aminogram analysis revealed that P. yoelii infection caused drastic change of plasma and liver aminogram, and altered intra- and inter-correlation of amino acid concentration in plasma and liver. These findings of the interactions between amino acids and Plasmodium infection may provide insight to reveal the interaction between nutrients and parasites. BioMed Central 2013-01-16 /pmc/articles/PMC3551679/ /pubmed/23324562 http://dx.doi.org/10.1186/1475-2875-12-19 Text en Copyright ©2013 Saiki et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Methodology
Saiki, Erisha
Nagao, Kenji
Aonuma, Hiroka
Fukumoto, Shinya
Xuan, Xuenan
Bannai, Makoto
Kanuka, Hirotaka
Multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite Plasmodium yoelii
title Multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite Plasmodium yoelii
title_full Multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite Plasmodium yoelii
title_fullStr Multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite Plasmodium yoelii
title_full_unstemmed Multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite Plasmodium yoelii
title_short Multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite Plasmodium yoelii
title_sort multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite plasmodium yoelii
topic Methodology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551679/
https://www.ncbi.nlm.nih.gov/pubmed/23324562
http://dx.doi.org/10.1186/1475-2875-12-19
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