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Factors associated with latent tuberculosis among asylum seekers in Switzerland: a cross-sectional study in Vaud County

BACKGROUND: Screening and treatment of latent tuberculosis infection (LTBI) in asylum seekers (AS) may prevent future cases of tuberculosis. As the screening with Interferon Gamma Release Assay (IGRA) is costly, the objective of this study was to assess which factors were associated with LTBI and to...

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Autores principales: Sarivalasis, Apostolos, Zellweger, Jean-Pierre, Faouzi, Mohamed, Daher, Oscar, Deslarzes, Charlotte, Bodenmann, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551725/
https://www.ncbi.nlm.nih.gov/pubmed/23121680
http://dx.doi.org/10.1186/1471-2334-12-285
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author Sarivalasis, Apostolos
Zellweger, Jean-Pierre
Faouzi, Mohamed
Daher, Oscar
Deslarzes, Charlotte
Bodenmann, Patrick
author_facet Sarivalasis, Apostolos
Zellweger, Jean-Pierre
Faouzi, Mohamed
Daher, Oscar
Deslarzes, Charlotte
Bodenmann, Patrick
author_sort Sarivalasis, Apostolos
collection PubMed
description BACKGROUND: Screening and treatment of latent tuberculosis infection (LTBI) in asylum seekers (AS) may prevent future cases of tuberculosis. As the screening with Interferon Gamma Release Assay (IGRA) is costly, the objective of this study was to assess which factors were associated with LTBI and to define a score allowing the selection of AS with the highest risk of LTBI. METHODS: In across-sectional study, AS seekers recently arrived in Vaud County, after screening for tuberculosis at the border were offered screening for LTBI with T-SPOT.TB and questionnaire on potentially risk factors. The factors associated with LTBI were analyzed by univariate and multivariate regression. RESULTS: Among 393 adult AS, 98 (24.93%) had a positive IGRA response, five of them with active tuberculosis previously undetected. Six factors associated with LTBI were identified in multivariate analysis: origin, travel conditions, marital status, cough, age and prior TB exposure. Their combination leads to a robust LTBI predictive score. CONCLUSIONS: The prevalence of LTBI and active tuberculosis in AS is high. A predictive score integrating six factors could identify the asylum seekers with the highest risk for LTBI.
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spelling pubmed-35517252013-01-24 Factors associated with latent tuberculosis among asylum seekers in Switzerland: a cross-sectional study in Vaud County Sarivalasis, Apostolos Zellweger, Jean-Pierre Faouzi, Mohamed Daher, Oscar Deslarzes, Charlotte Bodenmann, Patrick BMC Infect Dis Research Article BACKGROUND: Screening and treatment of latent tuberculosis infection (LTBI) in asylum seekers (AS) may prevent future cases of tuberculosis. As the screening with Interferon Gamma Release Assay (IGRA) is costly, the objective of this study was to assess which factors were associated with LTBI and to define a score allowing the selection of AS with the highest risk of LTBI. METHODS: In across-sectional study, AS seekers recently arrived in Vaud County, after screening for tuberculosis at the border were offered screening for LTBI with T-SPOT.TB and questionnaire on potentially risk factors. The factors associated with LTBI were analyzed by univariate and multivariate regression. RESULTS: Among 393 adult AS, 98 (24.93%) had a positive IGRA response, five of them with active tuberculosis previously undetected. Six factors associated with LTBI were identified in multivariate analysis: origin, travel conditions, marital status, cough, age and prior TB exposure. Their combination leads to a robust LTBI predictive score. CONCLUSIONS: The prevalence of LTBI and active tuberculosis in AS is high. A predictive score integrating six factors could identify the asylum seekers with the highest risk for LTBI. BioMed Central 2012-11-02 /pmc/articles/PMC3551725/ /pubmed/23121680 http://dx.doi.org/10.1186/1471-2334-12-285 Text en Copyright ©2012 Sarivalasis et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sarivalasis, Apostolos
Zellweger, Jean-Pierre
Faouzi, Mohamed
Daher, Oscar
Deslarzes, Charlotte
Bodenmann, Patrick
Factors associated with latent tuberculosis among asylum seekers in Switzerland: a cross-sectional study in Vaud County
title Factors associated with latent tuberculosis among asylum seekers in Switzerland: a cross-sectional study in Vaud County
title_full Factors associated with latent tuberculosis among asylum seekers in Switzerland: a cross-sectional study in Vaud County
title_fullStr Factors associated with latent tuberculosis among asylum seekers in Switzerland: a cross-sectional study in Vaud County
title_full_unstemmed Factors associated with latent tuberculosis among asylum seekers in Switzerland: a cross-sectional study in Vaud County
title_short Factors associated with latent tuberculosis among asylum seekers in Switzerland: a cross-sectional study in Vaud County
title_sort factors associated with latent tuberculosis among asylum seekers in switzerland: a cross-sectional study in vaud county
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551725/
https://www.ncbi.nlm.nih.gov/pubmed/23121680
http://dx.doi.org/10.1186/1471-2334-12-285
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