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T-cell activation by treatment of cancer patients with EMD 521873 (Selectikine), an IL-2/anti-DNA fusion protein

BACKGROUND: EMD 521873 (Selectikine or NHS-IL2LT) is a fusion protein consisting of modified human IL-2 which binds specifically to the high-affinity IL-2 receptor, and an antibody specific for both single- and double-stranded DNA, designed to facilitate the enrichment of IL-2 in tumor tissue. METHO...

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Detalles Bibliográficos
Autores principales:	Laurent, Julien, Touvrey, Cedric, Gillessen, Silke, Joffraud, Magali, Vicari, Manuela, Bertrand, Caroline, Ongarello, Stefano, Liedert, Bernd, Gallerani, Elisa, Beck, Joachim, Omlin, Aurelius, Sessa, Cristiana, Quaratino, Sonia, Stupp, Roger, Gnad-Vogt, Ulrike S, Speiser, Daniel E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551760/ https://www.ncbi.nlm.nih.gov/pubmed/23294527 http://dx.doi.org/10.1186/1479-5876-11-5

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