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An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet

Recent studies have shown cytoplasmic droplets to be normal morphological occurrences in human male spermatozoa. When the cytoplasm around the sperm midpiece is present in large amounts, however, pathological effects may transpire. The cytoplasmic droplet then becomes known as excess residual cytopl...

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Autores principales: Rengan, Anil K, Agarwal, Ashok, van der Linde, Michelle, du Plessis, Stefan S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551780/
https://www.ncbi.nlm.nih.gov/pubmed/23159014
http://dx.doi.org/10.1186/1477-7827-10-92
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author Rengan, Anil K
Agarwal, Ashok
van der Linde, Michelle
du Plessis, Stefan S
author_facet Rengan, Anil K
Agarwal, Ashok
van der Linde, Michelle
du Plessis, Stefan S
author_sort Rengan, Anil K
collection PubMed
description Recent studies have shown cytoplasmic droplets to be normal morphological occurrences in human male spermatozoa. When the cytoplasm around the sperm midpiece is present in large amounts, however, pathological effects may transpire. The cytoplasmic droplet then becomes known as excess residual cytoplasm, which can impair overall sperm function and produce higher levels of reactive oxygen species, potentially leading to male infertility. Though the distinction between cytoplasmic droplets and excess residual cytoplasm has been made, some studies fail to recognize the difference and incorrectly label the latter as a cytoplasmic droplet. This review attempts to clarify excess residual cytoplasm’s effect on fertility, examine the enzymes responsible, and suggest tests and possible treatment options for those affected by this defect.
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spelling pubmed-35517802013-01-24 An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet Rengan, Anil K Agarwal, Ashok van der Linde, Michelle du Plessis, Stefan S Reprod Biol Endocrinol Review Recent studies have shown cytoplasmic droplets to be normal morphological occurrences in human male spermatozoa. When the cytoplasm around the sperm midpiece is present in large amounts, however, pathological effects may transpire. The cytoplasmic droplet then becomes known as excess residual cytoplasm, which can impair overall sperm function and produce higher levels of reactive oxygen species, potentially leading to male infertility. Though the distinction between cytoplasmic droplets and excess residual cytoplasm has been made, some studies fail to recognize the difference and incorrectly label the latter as a cytoplasmic droplet. This review attempts to clarify excess residual cytoplasm’s effect on fertility, examine the enzymes responsible, and suggest tests and possible treatment options for those affected by this defect. BioMed Central 2012-11-17 /pmc/articles/PMC3551780/ /pubmed/23159014 http://dx.doi.org/10.1186/1477-7827-10-92 Text en Copyright ©2012 Rengan et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Rengan, Anil K
Agarwal, Ashok
van der Linde, Michelle
du Plessis, Stefan S
An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet
title An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet
title_full An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet
title_fullStr An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet
title_full_unstemmed An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet
title_short An investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet
title_sort investigation of excess residual cytoplasm in human spermatozoa and its distinction from the cytoplasmic droplet
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551780/
https://www.ncbi.nlm.nih.gov/pubmed/23159014
http://dx.doi.org/10.1186/1477-7827-10-92
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