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Temperature-Dependent Structural Changes of Parkinson's Alpha-Synuclein Reveal the Role of Pre-Existing Oligomers in Alpha-Synuclein Fibrillization

Amyloid fibrils of α-synuclein are the main constituent of Lewy bodies deposited in substantial nigra of Parkinson's disease brains. α-Synuclein is an intrinsically disordered protein lacking compact secondary and tertiary structures. To enhance the understanding of its structure and function r...

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Detalles Bibliográficos
Autores principales:	Ariesandi, Winny, Chang, Chi-Fon, Chen, Tseng-Erh, Chen, Yun-Ru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551866/ https://www.ncbi.nlm.nih.gov/pubmed/23349712 http://dx.doi.org/10.1371/journal.pone.0053487

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