TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults

HIV-patients have excess of pneumococcal infection. We immunized 40 HIV-patients twice with pneumococcal conjugate vaccine (Prevnar, Pfizer) +/− a TLR9 agonist (CPG 7909). Peripheral blood mononuclear cells were stimulated with pneumococcal polysaccharides and cytokine concentrations measured. The C...

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Detalles Bibliográficos
Autores principales: Offersen, Rasmus, Melchjorsen, Jesper, Paludan, Søren R., Østergaard, Lars, Tolstrup, Martin, Søgaard, Ole S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551874/
https://www.ncbi.nlm.nih.gov/pubmed/22854665
http://dx.doi.org/10.4161/hv.20707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551874/
https://www.ncbi.nlm.nih.gov/pubmed/22854665
http://dx.doi.org/10.4161/hv.20707

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