Cargando…

Dact2 Represses PITX2 Transcriptional Activation and Cell Proliferation through Wnt/beta-Catenin Signaling during Odontogenesis

Dact proteins belong to the Dapper/Frodo protein family and function as cytoplasmic attenuators in Wnt and TGFβ signaling. Previous studies show that Dact1 is a potent Wnt signaling inhibitor by promoting degradation of β-catenin. We report a new mechanism for Dact2 function as an inhibitor of the c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xiao, Florez, Sergio, Wang, Jianbo, Cao, Huojun, Amendt, Brad A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551926/ https://www.ncbi.nlm.nih.gov/pubmed/23349981 http://dx.doi.org/10.1371/journal.pone.0054868

Ejemplares similares

Procaine Inhibits Osteo/Odontogenesis through Wnt/β-Catenin Inactivation
por: Herencia, Carmen, et al.
Publicado: (2016)

HMGN2 represses gene transcription via interaction with transcription factors Lef-1 and Pitx2 during amelogenesis
por: Eliason, Steven, et al.
Publicado: (2022)

DACT1, an antagonist to Wnt/β-catenin signaling, suppresses tumor cell growth and is frequently silenced in breast cancer
por: Yin, Xuedong, et al.
Publicado: (2013)

PITX2 in pancreatic stellate cells promotes EMT in pancreatic cancer cells via the Wnt/β-catenin pathway: PITX2 promotes pancreatic cancer progression via Wnt/β-catenin pathway
por: Wu, Di, et al.
Publicado: (2023)

CKD-581 Downregulates Wnt/β-Catenin Pathway by DACT3 Induction in Hematologic Malignancy
por: Kim, Soo Jin, et al.
Publicado: (2022)

Spatiotemporal Expression of Wnt/β-catenin Signaling during Morphogenesis and Odontogenesis of Deciduous Molar in Miniature Pig
por: Wu, Xiaoshan, et al.
Publicado: (2017)

TGF-β-induced DACT1 Biomolecular Condensates Repress Wnt Signaling To Promote Bone Metastasis
por: Esposito, Mark, et al.
Publicado: (2021)

PITX2 enhances progression of lung adenocarcinoma by transcriptionally regulating WNT3A and activating Wnt/β-catenin signaling pathway
por: Luo, Jing, et al.
Publicado: (2019)

Pitx2 Regulates Procollagen Lysyl Hydroxylase (Plod) Gene Expression: Implications for the Pathology of Rieger Syndrome
por: Hjalt, Tord A., et al.
Publicado: (2001)

Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation
por: Shang, Yueting, et al.
Publicado: (2008)

Wnt/β-Catenin Regulates the Activity of Epiprofin/Sp6, SHH, FGF, and BMP to Coordinate the Stages of Odontogenesis
por: Aurrekoetxea, Maitane, et al.
Publicado: (2016)

Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling
por: Zhang, Meiying, et al.
Publicado: (2016)

Methylation of DACT2 promotes breast cancer development by activating Wnt signaling
por: Li, Jingyi, et al.
Publicado: (2017)

DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer
por: Wang, S, et al.
Publicado: (2015)

A novel mutation of SATB2 inhibits odontogenesis of human dental pulp stem cells through Wnt/β-catenin signaling pathway
por: Xin, Tianyi, et al.
Publicado: (2021)

Dact1, a Nutritionally Regulated Preadipocyte Gene, Controls Adipogenesis by Coordinating the Wnt/β-Catenin Signaling Network
por: Lagathu, Claire, et al.
Publicado: (2009)

Methylation of DACT2 Promotes Papillary Thyroid Cancer Metastasis by Activating Wnt Signaling
por: Zhao, Zhiyan, et al.
Publicado: (2014)

Oncogenic Function of DACT1 in Colon Cancer through the Regulation of β-catenin
por: Yuan, Guohong, et al.
Publicado: (2012)

Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury
por: Tao, Ge, et al.
Publicado: (2016)

Expression and Function of NUMB in Odontogenesis
por: Li, Haitao, et al.
Publicado: (2013)

TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells
por: Fan, Jiangxia, et al.
Publicado: (2018)

Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/β-catenin signaling
por: Amen, Melanie, et al.
Publicado: (2008)

Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma
por: Guo, Yan-li, et al.
Publicado: (2017)

Wolf-Hirschhorn syndrome candidate 1 (Whsc1) methyltransferase signals via a Pitx2-miR-23/24 axis to effect tooth development
por: Su, Dan, et al.
Publicado: (2023)

Dact genes are chordate specific regulators at the intersection of Wnt and Tgf-β signaling pathways
por: Schubert, Frank Richard, et al.
Publicado: (2014)

Repression of Wnt/β-catenin signaling by SOX9 and Mastermind-like transcriptional coactivator 2
por: Sinha, Abhishek, et al.
Publicado: (2021)

MiR-324-3p promotes tumor growth through targeting DACT1 and activation of Wnt/β-catenin pathway in hepatocellular carcinoma
por: Tuo, Hang, et al.
Publicado: (2017)

Dapper Antagonist of Catenin-1 (Dact1) contributes to dendrite arborization in forebrain cortical interneurons
por: Arguello, Annie, et al.
Publicado: (2013)

dact1/2 modifies noncanonical Wnt signaling and calpain 8 expression to regulate convergent extension and craniofacial development
por: Carroll, Shannon H., et al.
Publicado: (2023)

α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes
por: Choi, Seung H., et al.
Publicado: (2013)

Coordination of WNT signaling and ciliogenesis during odontogenesis by piezo type mechanosensitive ion channel component 1
por: Miyazaki, Aya, et al.
Publicado: (2019)

Foxf2 represses bone formation via Wnt2b/β-catenin signaling
por: Tanaka, Tomoyuki, et al.
Publicado: (2022)

MENA Is a Transcriptional Target of the Wnt/Beta-Catenin Pathway
por: Najafov, Ayaz, et al.
Publicado: (2012)

Dact1 Regulates the Ability of 3T3-J2 Cells to Support Proliferation of Human Epidermal Keratinocytes
por: Suzuki, Daisuke, et al.
Publicado: (2015)

Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway
por: Tan, Ying, et al.
Publicado: (2017)

DACT2 regulates structural and electrical atrial remodeling in atrial fibrillation
por: Hou, Jian, et al.
Publicado: (2020)

Demethylzelasteral inhibits proliferation and EMT via repressing Wnt/β-catenin signaling in esophageal squamous cell carcinoma
por: Yu, Jiarui, et al.
Publicado: (2021)

Pitx2 in Embryonic and Adult Myogenesis
por: Hernandez-Torres, Francisco, et al.
Publicado: (2017)

Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice
por: Matsubara, Tomoko, et al.
Publicado: (2022)

Role of Cell Death in Cellular Processes During Odontogenesis
por: Abramyan, John, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_e7poqdun8dj02cqi3m288cmubr