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Dact2 Represses PITX2 Transcriptional Activation and Cell Proliferation through Wnt/beta-Catenin Signaling during Odontogenesis

Dact proteins belong to the Dapper/Frodo protein family and function as cytoplasmic attenuators in Wnt and TGFβ signaling. Previous studies show that Dact1 is a potent Wnt signaling inhibitor by promoting degradation of β-catenin. We report a new mechanism for Dact2 function as an inhibitor of the c...

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Detalles Bibliográficos
Autores principales:	Li, Xiao, Florez, Sergio, Wang, Jianbo, Cao, Huojun, Amendt, Brad A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551926/ https://www.ncbi.nlm.nih.gov/pubmed/23349981 http://dx.doi.org/10.1371/journal.pone.0054868

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