Cargando…

IL-7 signaling must be intermittent, not continuous, during CD8 T cell homeostasis to promote cell survival instead of cell death

Maintenance of naive CD8 T cells is necessary for lifelong immunocompetence but for unknown reasons requires both interleukin-7 (IL-7) and T cell receptor (TCR) signaling. We now report that naive CD8 T cells require IL-7 signaling to be intermittent, not continuous, because prolonged IL-7 signaling...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kimura, Motoko Y., Pobezinsky, Leonid A., Guinter, Terry, Thomas, Julien, Adams, Anthony, Park, Jung-Hyun, Tai, Xuguang, Singer, Alfred
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552087/ https://www.ncbi.nlm.nih.gov/pubmed/23242416 http://dx.doi.org/10.1038/ni.2494

Ejemplares similares

Let-7 miRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function
por: Pobezinsky, Leonid A., et al.
Publicado: (2015)

Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation
por: Erman, Batu, et al.
Publicado: (2004)

Identification of lineage-specifying cytokines that signal all CD8-cytotoxic lineage fate decisions in the thymus
por: Etzensperger, Ruth, et al.
Publicado: (2017)

Unraveling a Revealing Paradox: Why Major Histocompatibility Complex I–signaled Thymocytes “Paradoxically” Appear as CD4(+)8(lo) Transitional Cells During Positive Selection of CD8(+) T Cells
por: Bosselut, Remy, et al.
Publicado: (2003)

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection
por: Pobezinsky, Leonid A., et al.
Publicado: (2012)

Survival of Naïve T Cells Requires the Expression of Let-7 miRNAs
por: Pobezinskaya, Elena L., et al.
Publicado: (2019)

E-protein–regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex
por: Kadakia, Tejas, et al.
Publicado: (2019)

How autoreactive thymocytes differentiate into regulatory versus effector CD4(+) T cells after avoiding clonal deletion
por: Tai, Xuguang, et al.
Publicado: (2023)

Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus
por: Shinzawa, Miho, et al.
Publicado: (2022)

Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus
por: Van Laethem, François, et al.
Publicado: (2020)

Cell therapy must be regulated as medicine
por: Li, Zihai, et al.
Publicado: (2016)

Why must T cells be cross-reactive?
por: Sewell, Andrew K.
Publicado: (2012)

No axions, but what instead ?
Publicado: (1978)

Spreading instead of growing
por: Bashyam, Hema
Publicado: (2008)

Castration Instead of Lynching
Publicado: (1906)

Castration Instead of Lynching
Publicado: (1907)

Milk Instead of Medicine
Publicado: (1893)

Cytokinesis D is Mediated by Cortical Flow of Dividing Cells Instead of Chemotaxis
por: Tanaka, Yuki, et al.
Publicado: (2019)

Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus
por: McCaughtry, Tom M., et al.
Publicado: (2012)

The small intestine epithelium exempts Foxp3+ Tregs from their IL-2 requirement for homeostasis and effector function
por: Prakhar, Praveen, et al.
Publicado: (2021)

Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis
por: Angelou, Constance C., et al.
Publicado: (2020)

Chemical Exposures Affect Innate Immune Response to SARS-CoV-2
por: Arowolo, Olatunbosun, et al.
Publicado: (2021)

IL-2–dependent adaptive control of NK cell homeostasis
por: Gasteiger, Georg, et al.
Publicado: (2013)

Host with the most: Targeting host cells instead of pathogens to fight infectious disease
por: Keener, Amanda B.
Publicado: (2017)

Universal Democracy Instead of Anarchy
por: Branco, G.C., et al.
Publicado: (2013)

Secretion of Blood Instead of Milk
Publicado: (1890)

IL‐4 and IL‐13 both contribute to the homeostasis of human conjunctival goblet cells in vitro
por: Hansen, Pernille M., et al.
Publicado: (2022)

Must
Publicado: (1892)

How Prostate Cancer Cells Use Strategy Instead of Brute Force to Achieve Metastasis
por: Tharp, Darron, et al.
Publicado: (2019)

Tendon Cells Root Into (Instead of Attach to) Humeral Bone Head via Fibrocartilage-Enthesis
por: Wang, Zheng, et al.
Publicado: (2023)

Effects of intermittent pressure imitating rolling manipulation on calcium ion homeostasis in human skeletal muscle cells
por: Zhang, Hong, et al.
Publicado: (2016)

Shp1 regulates T cell homeostasis by limiting IL-4 signals
por: Johnson, Dylan J., et al.
Publicado: (2013)

Fructose and Cardiometabolic Disorders: The Controversy Will, and Must, Continue
por: Wiernsperger, Nicolas, et al.
Publicado: (2010)

Gene Expression in Barrett’s Esophagus Cell Lines Resemble Esophageal Squamous Cell Carcinoma Instead of Esophageal Adenocarcinoma
por: Panda, Anshuman, et al.
Publicado: (2021)

Beyond the Bench: Help Instead of Hype
por: Dooley, Erin E.
Publicado: (2004)

The Risk of Treating Populations Instead of Patients
por: Deitchman, Amelia N.
Publicado: (2019)

The Need to Focus on Therapy Instead of Associations
por: Reid, Gregor
Publicado: (2019)

Silole allylic anions instead of silanides
por: Pöcheim, Alexander, et al.
Publicado: (2021)

Time to Prescribe Dual instead of Mono
por: Choi, Joon Young
Publicado: (2021)

“Health First” Instead of “Safety First”
por: Carrick, M. M.
Publicado: (1914)

Cannot write session to /tmp/vufind_sessions/sess_g1190m10af8p9nbv9pohljcn3q