Kynurenic Acid in Plasma and Endometrium in Bitches with Pyometra

Kynurenic acid (KYNA) is produced enzymatically in humans and animals from kynurenine. Reports concerning changes of kynurenine metabolism during inflammation are available in the literature. Pyometra is a pathological condition characterized by the accumulation of pus in the uterine lumen and bacte...

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Autores principales: Dąbrowski, Roman, Kocki, Tomasz, Szczubiał, Marek, Dąbrowski, Wojciech, Parada-Turska, Jolanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552364/
https://www.ncbi.nlm.nih.gov/pubmed/22915278
http://dx.doi.org/10.1007/s10753-012-9527-5
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author Dąbrowski, Roman
Kocki, Tomasz
Szczubiał, Marek
Dąbrowski, Wojciech
Parada-Turska, Jolanta
author_facet Dąbrowski, Roman
Kocki, Tomasz
Szczubiał, Marek
Dąbrowski, Wojciech
Parada-Turska, Jolanta
author_sort Dąbrowski, Roman
collection PubMed
description Kynurenic acid (KYNA) is produced enzymatically in humans and animals from kynurenine. Reports concerning changes of kynurenine metabolism during inflammation are available in the literature. Pyometra is a pathological condition characterized by the accumulation of pus in the uterine lumen and bacterial infection. The objective of the study was to compare the serum and endometrial KYNA concentrations in healthy bitches and those with pyometra. KYNA was determined by means of high-performance liquid chromatography with fluorometric detection. The serum content of KYNA in bitches with pyometra was significantly higher than in healthy bitches. The KYNA content in the endometrium of bitches with pyometra was higher, yet the difference was not statistically significant. Our result indicates that determination of KYNA might be a marker of pyometra in bitches.
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spelling pubmed-35523642013-01-24 Kynurenic Acid in Plasma and Endometrium in Bitches with Pyometra Dąbrowski, Roman Kocki, Tomasz Szczubiał, Marek Dąbrowski, Wojciech Parada-Turska, Jolanta Inflammation Article Kynurenic acid (KYNA) is produced enzymatically in humans and animals from kynurenine. Reports concerning changes of kynurenine metabolism during inflammation are available in the literature. Pyometra is a pathological condition characterized by the accumulation of pus in the uterine lumen and bacterial infection. The objective of the study was to compare the serum and endometrial KYNA concentrations in healthy bitches and those with pyometra. KYNA was determined by means of high-performance liquid chromatography with fluorometric detection. The serum content of KYNA in bitches with pyometra was significantly higher than in healthy bitches. The KYNA content in the endometrium of bitches with pyometra was higher, yet the difference was not statistically significant. Our result indicates that determination of KYNA might be a marker of pyometra in bitches. Springer US 2012-08-23 2013 /pmc/articles/PMC3552364/ /pubmed/22915278 http://dx.doi.org/10.1007/s10753-012-9527-5 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Dąbrowski, Roman
Kocki, Tomasz
Szczubiał, Marek
Dąbrowski, Wojciech
Parada-Turska, Jolanta
Kynurenic Acid in Plasma and Endometrium in Bitches with Pyometra
title Kynurenic Acid in Plasma and Endometrium in Bitches with Pyometra
title_full Kynurenic Acid in Plasma and Endometrium in Bitches with Pyometra
title_fullStr Kynurenic Acid in Plasma and Endometrium in Bitches with Pyometra
title_full_unstemmed Kynurenic Acid in Plasma and Endometrium in Bitches with Pyometra
title_short Kynurenic Acid in Plasma and Endometrium in Bitches with Pyometra
title_sort kynurenic acid in plasma and endometrium in bitches with pyometra
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552364/
https://www.ncbi.nlm.nih.gov/pubmed/22915278
http://dx.doi.org/10.1007/s10753-012-9527-5
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