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Integration method of 3D MR spectroscopy into treatment planning system for glioblastoma IMRT dose painting with integrated simultaneous boost

BACKGROUND: To integrate 3D MR spectroscopy imaging (MRSI) in the treatment planning system (TPS) for glioblastoma dose painting to guide simultaneous integrated boost (SIB) in intensity-modulated radiation therapy (IMRT). METHODS: For sixteen glioblastoma patients, we have simulated three types of...

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Autores principales: Ken, Soléakhéna, Vieillevigne, Laure, Franceries, Xavier, Simon, Luc, Supper, Caroline, Lotterie, Jean-Albert, Filleron, Thomas, Lubrano, Vincent, Berry, Isabelle, Cassol, Emmanuelle, Delannes, Martine, Celsis, Pierre, Cohen-Jonathan, Elizabeth Moyal, Laprie, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552736/
https://www.ncbi.nlm.nih.gov/pubmed/23280007
http://dx.doi.org/10.1186/1748-717X-8-1
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author Ken, Soléakhéna
Vieillevigne, Laure
Franceries, Xavier
Simon, Luc
Supper, Caroline
Lotterie, Jean-Albert
Filleron, Thomas
Lubrano, Vincent
Berry, Isabelle
Cassol, Emmanuelle
Delannes, Martine
Celsis, Pierre
Cohen-Jonathan, Elizabeth Moyal
Laprie, Anne
author_facet Ken, Soléakhéna
Vieillevigne, Laure
Franceries, Xavier
Simon, Luc
Supper, Caroline
Lotterie, Jean-Albert
Filleron, Thomas
Lubrano, Vincent
Berry, Isabelle
Cassol, Emmanuelle
Delannes, Martine
Celsis, Pierre
Cohen-Jonathan, Elizabeth Moyal
Laprie, Anne
author_sort Ken, Soléakhéna
collection PubMed
description BACKGROUND: To integrate 3D MR spectroscopy imaging (MRSI) in the treatment planning system (TPS) for glioblastoma dose painting to guide simultaneous integrated boost (SIB) in intensity-modulated radiation therapy (IMRT). METHODS: For sixteen glioblastoma patients, we have simulated three types of dosimetry plans, one conventional plan of 60-Gy in 3D conformational radiotherapy (3D-CRT), one 60-Gy plan in IMRT and one 72-Gy plan in SIB-IMRT. All sixteen MRSI metabolic maps were integrated into TPS, using normalization with color-space conversion and threshold-based segmentation. The fusion between the metabolic maps and the planning CT scans were assessed. Dosimetry comparisons were performed between the different plans of 60-Gy 3D-CRT, 60-Gy IMRT and 72-Gy SIB-IMRT, the last plan was targeted on MRSI abnormalities and contrast enhancement (CE). RESULTS: Fusion assessment was performed for 160 transformations. It resulted in maximum differences <1.00 mm for translation parameters and ≤1.15° for rotation. Dosimetry plans of 72-Gy SIB-IMRT and 60-Gy IMRT showed a significantly decreased maximum dose to the brainstem (44.00 and 44.30 vs. 57.01 Gy) and decreased high dose-volumes to normal brain (19 and 20 vs. 23% and 7 and 7 vs. 12%) compared to 60-Gy 3D-CRT (p < 0.05). CONCLUSIONS: Delivering standard doses to conventional target and higher doses to new target volumes characterized by MRSI and CE is now possible and does not increase dose to organs at risk. MRSI and CE abnormalities are now integrated for glioblastoma SIB-IMRT, concomitant with temozolomide, in an ongoing multi-institutional phase-III clinical trial. Our method of MR spectroscopy maps integration to TPS is robust and reliable; integration to neuronavigation systems with this method could also improve glioblastoma resection or guide biopsies.
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spelling pubmed-35527362013-01-28 Integration method of 3D MR spectroscopy into treatment planning system for glioblastoma IMRT dose painting with integrated simultaneous boost Ken, Soléakhéna Vieillevigne, Laure Franceries, Xavier Simon, Luc Supper, Caroline Lotterie, Jean-Albert Filleron, Thomas Lubrano, Vincent Berry, Isabelle Cassol, Emmanuelle Delannes, Martine Celsis, Pierre Cohen-Jonathan, Elizabeth Moyal Laprie, Anne Radiat Oncol Methodology BACKGROUND: To integrate 3D MR spectroscopy imaging (MRSI) in the treatment planning system (TPS) for glioblastoma dose painting to guide simultaneous integrated boost (SIB) in intensity-modulated radiation therapy (IMRT). METHODS: For sixteen glioblastoma patients, we have simulated three types of dosimetry plans, one conventional plan of 60-Gy in 3D conformational radiotherapy (3D-CRT), one 60-Gy plan in IMRT and one 72-Gy plan in SIB-IMRT. All sixteen MRSI metabolic maps were integrated into TPS, using normalization with color-space conversion and threshold-based segmentation. The fusion between the metabolic maps and the planning CT scans were assessed. Dosimetry comparisons were performed between the different plans of 60-Gy 3D-CRT, 60-Gy IMRT and 72-Gy SIB-IMRT, the last plan was targeted on MRSI abnormalities and contrast enhancement (CE). RESULTS: Fusion assessment was performed for 160 transformations. It resulted in maximum differences <1.00 mm for translation parameters and ≤1.15° for rotation. Dosimetry plans of 72-Gy SIB-IMRT and 60-Gy IMRT showed a significantly decreased maximum dose to the brainstem (44.00 and 44.30 vs. 57.01 Gy) and decreased high dose-volumes to normal brain (19 and 20 vs. 23% and 7 and 7 vs. 12%) compared to 60-Gy 3D-CRT (p < 0.05). CONCLUSIONS: Delivering standard doses to conventional target and higher doses to new target volumes characterized by MRSI and CE is now possible and does not increase dose to organs at risk. MRSI and CE abnormalities are now integrated for glioblastoma SIB-IMRT, concomitant with temozolomide, in an ongoing multi-institutional phase-III clinical trial. Our method of MR spectroscopy maps integration to TPS is robust and reliable; integration to neuronavigation systems with this method could also improve glioblastoma resection or guide biopsies. BioMed Central 2013-01-02 /pmc/articles/PMC3552736/ /pubmed/23280007 http://dx.doi.org/10.1186/1748-717X-8-1 Text en Copyright ©2013 Ken et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Methodology
Ken, Soléakhéna
Vieillevigne, Laure
Franceries, Xavier
Simon, Luc
Supper, Caroline
Lotterie, Jean-Albert
Filleron, Thomas
Lubrano, Vincent
Berry, Isabelle
Cassol, Emmanuelle
Delannes, Martine
Celsis, Pierre
Cohen-Jonathan, Elizabeth Moyal
Laprie, Anne
Integration method of 3D MR spectroscopy into treatment planning system for glioblastoma IMRT dose painting with integrated simultaneous boost
title Integration method of 3D MR spectroscopy into treatment planning system for glioblastoma IMRT dose painting with integrated simultaneous boost
title_full Integration method of 3D MR spectroscopy into treatment planning system for glioblastoma IMRT dose painting with integrated simultaneous boost
title_fullStr Integration method of 3D MR spectroscopy into treatment planning system for glioblastoma IMRT dose painting with integrated simultaneous boost
title_full_unstemmed Integration method of 3D MR spectroscopy into treatment planning system for glioblastoma IMRT dose painting with integrated simultaneous boost
title_short Integration method of 3D MR spectroscopy into treatment planning system for glioblastoma IMRT dose painting with integrated simultaneous boost
title_sort integration method of 3d mr spectroscopy into treatment planning system for glioblastoma imrt dose painting with integrated simultaneous boost
topic Methodology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552736/
https://www.ncbi.nlm.nih.gov/pubmed/23280007
http://dx.doi.org/10.1186/1748-717X-8-1
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