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Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT)

We report a case of 59-year-old Turkish man with history of mitral valve replacement (MVR) and chronic obstructive pulmonary disease (COPD) who was diagnosed with stage IIIA IgG lambda multiple myeloma (MM) in 1997. He underwent autologous hematopoietic stem cell transplantation after a conditioning...

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Autores principales: Sivgin, Serdar, Baldane, Suleyman, Kaynar, Leylagul, Kurnaz, Fatih, Baskol, Mevlut, Kula, Mustafa, Eroglu, Celalettin, Deniz, Kemal, Eser, Bulent, Unal, Ali, Cetin, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552783/
https://www.ncbi.nlm.nih.gov/pubmed/23350019
http://dx.doi.org/10.4084/MJHID.2013.006
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author Sivgin, Serdar
Baldane, Suleyman
Kaynar, Leylagul
Kurnaz, Fatih
Baskol, Mevlut
Kula, Mustafa
Eroglu, Celalettin
Deniz, Kemal
Eser, Bulent
Unal, Ali
Cetin, Mustafa
author_facet Sivgin, Serdar
Baldane, Suleyman
Kaynar, Leylagul
Kurnaz, Fatih
Baskol, Mevlut
Kula, Mustafa
Eroglu, Celalettin
Deniz, Kemal
Eser, Bulent
Unal, Ali
Cetin, Mustafa
author_sort Sivgin, Serdar
collection PubMed
description We report a case of 59-year-old Turkish man with history of mitral valve replacement (MVR) and chronic obstructive pulmonary disease (COPD) who was diagnosed with stage IIIA IgG lambda multiple myeloma (MM) in 1997. He underwent autologous hematopoietic stem cell transplantation after a conditioning regimen with melphalan 200mg per body area (m(2)) in February 2006. On February 2011, he was admitted to the emergency service of university hospital with complaints of hematemesis and melena. Pathological evaluation of gastric biopsy, obtained from a lesion of small gastric curvature, showed the gastric mucosa infiltrated by neoplastic plasma cells, monoclonal lambda light chain positive. The patient was considered as having local gastric relapsed disease and was treated with 2 cycles of bortezomib. He achieved an excellent local response after 2 cycles of bortezomib, cyclophosphamide and prednisone (BEP) regimen, with healing of gastric ulcer and no recurrence of the hematemesis or melena.
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spelling pubmed-35527832013-01-24 Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT) Sivgin, Serdar Baldane, Suleyman Kaynar, Leylagul Kurnaz, Fatih Baskol, Mevlut Kula, Mustafa Eroglu, Celalettin Deniz, Kemal Eser, Bulent Unal, Ali Cetin, Mustafa Mediterr J Hematol Infect Dis Case Report We report a case of 59-year-old Turkish man with history of mitral valve replacement (MVR) and chronic obstructive pulmonary disease (COPD) who was diagnosed with stage IIIA IgG lambda multiple myeloma (MM) in 1997. He underwent autologous hematopoietic stem cell transplantation after a conditioning regimen with melphalan 200mg per body area (m(2)) in February 2006. On February 2011, he was admitted to the emergency service of university hospital with complaints of hematemesis and melena. Pathological evaluation of gastric biopsy, obtained from a lesion of small gastric curvature, showed the gastric mucosa infiltrated by neoplastic plasma cells, monoclonal lambda light chain positive. The patient was considered as having local gastric relapsed disease and was treated with 2 cycles of bortezomib. He achieved an excellent local response after 2 cycles of bortezomib, cyclophosphamide and prednisone (BEP) regimen, with healing of gastric ulcer and no recurrence of the hematemesis or melena. Università Cattolica del Sacro Cuore 2013-01-02 /pmc/articles/PMC3552783/ /pubmed/23350019 http://dx.doi.org/10.4084/MJHID.2013.006 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Sivgin, Serdar
Baldane, Suleyman
Kaynar, Leylagul
Kurnaz, Fatih
Baskol, Mevlut
Kula, Mustafa
Eroglu, Celalettin
Deniz, Kemal
Eser, Bulent
Unal, Ali
Cetin, Mustafa
Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT)
title Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT)
title_full Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT)
title_fullStr Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT)
title_full_unstemmed Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT)
title_short Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT)
title_sort successful treatment of gastric relapse in multiple myeloma with bortezomib after autologous hematopoietic stem cell transplantation (autohsct)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552783/
https://www.ncbi.nlm.nih.gov/pubmed/23350019
http://dx.doi.org/10.4084/MJHID.2013.006
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