Cargando…
Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT)
We report a case of 59-year-old Turkish man with history of mitral valve replacement (MVR) and chronic obstructive pulmonary disease (COPD) who was diagnosed with stage IIIA IgG lambda multiple myeloma (MM) in 1997. He underwent autologous hematopoietic stem cell transplantation after a conditioning...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Università Cattolica del Sacro Cuore
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552783/ https://www.ncbi.nlm.nih.gov/pubmed/23350019 http://dx.doi.org/10.4084/MJHID.2013.006 |
_version_ | 1782256721683546112 |
---|---|
author | Sivgin, Serdar Baldane, Suleyman Kaynar, Leylagul Kurnaz, Fatih Baskol, Mevlut Kula, Mustafa Eroglu, Celalettin Deniz, Kemal Eser, Bulent Unal, Ali Cetin, Mustafa |
author_facet | Sivgin, Serdar Baldane, Suleyman Kaynar, Leylagul Kurnaz, Fatih Baskol, Mevlut Kula, Mustafa Eroglu, Celalettin Deniz, Kemal Eser, Bulent Unal, Ali Cetin, Mustafa |
author_sort | Sivgin, Serdar |
collection | PubMed |
description | We report a case of 59-year-old Turkish man with history of mitral valve replacement (MVR) and chronic obstructive pulmonary disease (COPD) who was diagnosed with stage IIIA IgG lambda multiple myeloma (MM) in 1997. He underwent autologous hematopoietic stem cell transplantation after a conditioning regimen with melphalan 200mg per body area (m(2)) in February 2006. On February 2011, he was admitted to the emergency service of university hospital with complaints of hematemesis and melena. Pathological evaluation of gastric biopsy, obtained from a lesion of small gastric curvature, showed the gastric mucosa infiltrated by neoplastic plasma cells, monoclonal lambda light chain positive. The patient was considered as having local gastric relapsed disease and was treated with 2 cycles of bortezomib. He achieved an excellent local response after 2 cycles of bortezomib, cyclophosphamide and prednisone (BEP) regimen, with healing of gastric ulcer and no recurrence of the hematemesis or melena. |
format | Online Article Text |
id | pubmed-3552783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Università Cattolica del Sacro Cuore |
record_format | MEDLINE/PubMed |
spelling | pubmed-35527832013-01-24 Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT) Sivgin, Serdar Baldane, Suleyman Kaynar, Leylagul Kurnaz, Fatih Baskol, Mevlut Kula, Mustafa Eroglu, Celalettin Deniz, Kemal Eser, Bulent Unal, Ali Cetin, Mustafa Mediterr J Hematol Infect Dis Case Report We report a case of 59-year-old Turkish man with history of mitral valve replacement (MVR) and chronic obstructive pulmonary disease (COPD) who was diagnosed with stage IIIA IgG lambda multiple myeloma (MM) in 1997. He underwent autologous hematopoietic stem cell transplantation after a conditioning regimen with melphalan 200mg per body area (m(2)) in February 2006. On February 2011, he was admitted to the emergency service of university hospital with complaints of hematemesis and melena. Pathological evaluation of gastric biopsy, obtained from a lesion of small gastric curvature, showed the gastric mucosa infiltrated by neoplastic plasma cells, monoclonal lambda light chain positive. The patient was considered as having local gastric relapsed disease and was treated with 2 cycles of bortezomib. He achieved an excellent local response after 2 cycles of bortezomib, cyclophosphamide and prednisone (BEP) regimen, with healing of gastric ulcer and no recurrence of the hematemesis or melena. Università Cattolica del Sacro Cuore 2013-01-02 /pmc/articles/PMC3552783/ /pubmed/23350019 http://dx.doi.org/10.4084/MJHID.2013.006 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Sivgin, Serdar Baldane, Suleyman Kaynar, Leylagul Kurnaz, Fatih Baskol, Mevlut Kula, Mustafa Eroglu, Celalettin Deniz, Kemal Eser, Bulent Unal, Ali Cetin, Mustafa Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT) |
title | Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT) |
title_full | Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT) |
title_fullStr | Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT) |
title_full_unstemmed | Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT) |
title_short | Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT) |
title_sort | successful treatment of gastric relapse in multiple myeloma with bortezomib after autologous hematopoietic stem cell transplantation (autohsct) |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552783/ https://www.ncbi.nlm.nih.gov/pubmed/23350019 http://dx.doi.org/10.4084/MJHID.2013.006 |
work_keys_str_mv | AT sivginserdar successfultreatmentofgastricrelapseinmultiplemyelomawithbortezomibafterautologoushematopoieticstemcelltransplantationautohsct AT baldanesuleyman successfultreatmentofgastricrelapseinmultiplemyelomawithbortezomibafterautologoushematopoieticstemcelltransplantationautohsct AT kaynarleylagul successfultreatmentofgastricrelapseinmultiplemyelomawithbortezomibafterautologoushematopoieticstemcelltransplantationautohsct AT kurnazfatih successfultreatmentofgastricrelapseinmultiplemyelomawithbortezomibafterautologoushematopoieticstemcelltransplantationautohsct AT baskolmevlut successfultreatmentofgastricrelapseinmultiplemyelomawithbortezomibafterautologoushematopoieticstemcelltransplantationautohsct AT kulamustafa successfultreatmentofgastricrelapseinmultiplemyelomawithbortezomibafterautologoushematopoieticstemcelltransplantationautohsct AT eroglucelalettin successfultreatmentofgastricrelapseinmultiplemyelomawithbortezomibafterautologoushematopoieticstemcelltransplantationautohsct AT denizkemal successfultreatmentofgastricrelapseinmultiplemyelomawithbortezomibafterautologoushematopoieticstemcelltransplantationautohsct AT eserbulent successfultreatmentofgastricrelapseinmultiplemyelomawithbortezomibafterautologoushematopoieticstemcelltransplantationautohsct AT unalali successfultreatmentofgastricrelapseinmultiplemyelomawithbortezomibafterautologoushematopoieticstemcelltransplantationautohsct AT cetinmustafa successfultreatmentofgastricrelapseinmultiplemyelomawithbortezomibafterautologoushematopoieticstemcelltransplantationautohsct |