Microautophagy in the visceral endoderm is essential for mouse early development

During early embryogenesis, before the conceptus forms the placenta, maternal nutrients as well as signaling molecules must reach the embryo proper through a tightly sealed epithelial tissue, the visceral endoderm (VE). The VE serves as a signaling center for embryogenesis, where exocytic and endocy...

Descripción completa

Detalles Bibliográficos
Autores principales: Wada, Yoh, Sun-Wada, Ge-Hong, Kawamura, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Autophagic Punctum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552893/
https://www.ncbi.nlm.nih.gov/pubmed/23108279
http://dx.doi.org/10.4161/auto.22585
_version_ 1782256742650871808
author Wada, Yoh
Sun-Wada, Ge-Hong
Kawamura, Nobuyuki
author_facet Wada, Yoh
Sun-Wada, Ge-Hong
Kawamura, Nobuyuki
author_sort Wada, Yoh
collection PubMed
description During early embryogenesis, before the conceptus forms the placenta, maternal nutrients as well as signaling molecules must reach the embryo proper through a tightly sealed epithelial tissue, the visceral endoderm (VE). The VE serves as a signaling center for embryogenesis, where exocytic and endocytic processes integrate signal production, perception and termination. However, the endocytic process in this important tissue has not been well characterized. We show that endocytic delivery to the lysosomes occurs via RAB7-dependent microautophagy. This process is essential for early mammalian development.
format Online
Article
Text
id pubmed-3552893
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-35528932013-02-13 Microautophagy in the visceral endoderm is essential for mouse early development Wada, Yoh Sun-Wada, Ge-Hong Kawamura, Nobuyuki Autophagy Autophagic Punctum During early embryogenesis, before the conceptus forms the placenta, maternal nutrients as well as signaling molecules must reach the embryo proper through a tightly sealed epithelial tissue, the visceral endoderm (VE). The VE serves as a signaling center for embryogenesis, where exocytic and endocytic processes integrate signal production, perception and termination. However, the endocytic process in this important tissue has not been well characterized. We show that endocytic delivery to the lysosomes occurs via RAB7-dependent microautophagy. This process is essential for early mammalian development. Landes Bioscience 2013-02-01 /pmc/articles/PMC3552893/ /pubmed/23108279 http://dx.doi.org/10.4161/auto.22585 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Autophagic Punctum
Wada, Yoh
Sun-Wada, Ge-Hong
Kawamura, Nobuyuki
Microautophagy in the visceral endoderm is essential for mouse early development
title Microautophagy in the visceral endoderm is essential for mouse early development
title_full Microautophagy in the visceral endoderm is essential for mouse early development
title_fullStr Microautophagy in the visceral endoderm is essential for mouse early development
title_full_unstemmed Microautophagy in the visceral endoderm is essential for mouse early development
title_short Microautophagy in the visceral endoderm is essential for mouse early development
title_sort microautophagy in the visceral endoderm is essential for mouse early development
topic Autophagic Punctum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552893/
https://www.ncbi.nlm.nih.gov/pubmed/23108279
http://dx.doi.org/10.4161/auto.22585
work_keys_str_mv AT wadayoh microautophagyinthevisceralendodermisessentialformouseearlydevelopment
AT sunwadagehong microautophagyinthevisceralendodermisessentialformouseearlydevelopment
AT kawamuranobuyuki microautophagyinthevisceralendodermisessentialformouseearlydevelopment

Ejemplares similares