Hypoxia, MTOR and autophagy: Converging on senescence or quiescence

Although hypoxia can cause cell cycle arrest, it may simultaneously suppress a conversion from this arrest to senescence. Furthermore, hypoxia can suppress senescence caused by diverse stimuli, maintaining reversible quiescence instead. Hypoxia activates autophagy and inhibits MTOR, thus also activa...

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Detalles Bibliográficos
Autor principal: Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Autophagic Punctum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552896/
https://www.ncbi.nlm.nih.gov/pubmed/23192222
http://dx.doi.org/10.4161/auto.22783
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author Blagosklonny, Mikhail V.
author_facet Blagosklonny, Mikhail V.
author_sort Blagosklonny, Mikhail V.
collection PubMed
description Although hypoxia can cause cell cycle arrest, it may simultaneously suppress a conversion from this arrest to senescence. Furthermore, hypoxia can suppress senescence caused by diverse stimuli, maintaining reversible quiescence instead. Hypoxia activates autophagy and inhibits MTOR, thus also activating autophagy. What is the relationship between autophagy and cellular senescence? Also, can inhibition of MTOR and stimulation of autophagy explain the gerosuppressive effects of hypoxia?
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spelling pubmed-35528962013-02-13 Hypoxia, MTOR and autophagy: Converging on senescence or quiescence Blagosklonny, Mikhail V. Autophagy Autophagic Punctum Although hypoxia can cause cell cycle arrest, it may simultaneously suppress a conversion from this arrest to senescence. Furthermore, hypoxia can suppress senescence caused by diverse stimuli, maintaining reversible quiescence instead. Hypoxia activates autophagy and inhibits MTOR, thus also activating autophagy. What is the relationship between autophagy and cellular senescence? Also, can inhibition of MTOR and stimulation of autophagy explain the gerosuppressive effects of hypoxia? Landes Bioscience 2013-02-01 /pmc/articles/PMC3552896/ /pubmed/23192222 http://dx.doi.org/10.4161/auto.22783 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Autophagic Punctum
Blagosklonny, Mikhail V.
Hypoxia, MTOR and autophagy: Converging on senescence or quiescence
title Hypoxia, MTOR and autophagy: Converging on senescence or quiescence
title_full Hypoxia, MTOR and autophagy: Converging on senescence or quiescence
title_fullStr Hypoxia, MTOR and autophagy: Converging on senescence or quiescence
title_full_unstemmed Hypoxia, MTOR and autophagy: Converging on senescence or quiescence
title_short Hypoxia, MTOR and autophagy: Converging on senescence or quiescence
title_sort hypoxia, mtor and autophagy: converging on senescence or quiescence
topic Autophagic Punctum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552896/
https://www.ncbi.nlm.nih.gov/pubmed/23192222
http://dx.doi.org/10.4161/auto.22783
work_keys_str_mv AT blagosklonnymikhailv hypoxiamtorandautophagyconvergingonsenescenceorquiescence

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