The Spectrum of SWI/SNF Mutations, Ubiquitous in Human Cancers

SWI/SNF is a multi-subunit chromatin remodeling complex that uses the energy of ATP hydrolysis to reposition nucleosomes, thereby modulating gene expression. Accumulating evidence suggests that SWI/SNF functions as a tumor suppressor in some cancers. However, the spectrum of SWI/SNF mutations across...

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Detalles Bibliográficos
Autores principales: Shain, A. Hunter, Pollack, Jonathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552954/
https://www.ncbi.nlm.nih.gov/pubmed/23355908
http://dx.doi.org/10.1371/journal.pone.0055119

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