Cargando…

An impaired health related muscular fitness contributes to a reduced walking capacity in patients with schizophrenia: a cross-sectional study

BACKGROUND: Patients with schizophrenia report muscle weakness. The relation of this muscle weakness with performing daily life activities such as walking is however not yet studied. The aim of this study was to quantify walking capacity and health related muscular fitness in patients with schizophr...

Descripción completa

Detalles Bibliográficos
Autores principales: Vancampfort, Davy, Probst, Michel, De Herdt, Amber, Corredeira, Rui Manuel Nunes, Carraro, Attilio, De Wachter, Dirk, De Hert, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553031/
https://www.ncbi.nlm.nih.gov/pubmed/23286356
http://dx.doi.org/10.1186/1471-244X-13-5
_version_ 1782256769537409024
author Vancampfort, Davy
Probst, Michel
De Herdt, Amber
Corredeira, Rui Manuel Nunes
Carraro, Attilio
De Wachter, Dirk
De Hert, Marc
author_facet Vancampfort, Davy
Probst, Michel
De Herdt, Amber
Corredeira, Rui Manuel Nunes
Carraro, Attilio
De Wachter, Dirk
De Hert, Marc
author_sort Vancampfort, Davy
collection PubMed
description BACKGROUND: Patients with schizophrenia report muscle weakness. The relation of this muscle weakness with performing daily life activities such as walking is however not yet studied. The aim of this study was to quantify walking capacity and health related muscular fitness in patients with schizophrenia compared with age-, gender and body mass index (BMI)-matched healthy controls. Secondly, we identified variables that could explain the variability in walking capacity and in health related muscular fitness in patients with schizophrenia. METHODS: A total of 100 patients with schizophrenia and 40 healthy volunteers were initially screened. Eighty patients with schizophrenia (36.8±10.0 years) and the 40 age-, gender- and body mass index (BMI)-matched healthy volunteers (37.1±10.3 years) were finally included. All participants performed a standing broad jump test (SBJ) and a six-minute walk test (6MWT) and filled out the International Physical Activity Questionnaire. Patients additionally had a fasting metabolic laboratory screening and were assessed for psychiatric symptoms. RESULTS: Patients with schizophrenia did have lower 6MWT (17.9%, p<0.001) [effect size (ES)=−1.01] and SBJ (14.1%, p<0.001) (ES=−0.57) scores. Patients were also less physically active (1291.0±1201.8 metabolic equivalent-minutes/week versus 2463.1±1365.3, p<0.001) (ES=−0.91) than controls. Schizophrenia patients with metabolic syndrome (MetS) (35%) had a 23.9% lower (p<0.001) SBJ-score and 22.4% (p<0.001) lower 6MWT-score than those without MetS. In multiple regression analysis, 71.8% of the variance in 6MWT was explained by muscular fitness, BMI, presence of MetS and physical activity participation, while 53.9% of the variance in SBJ-score was explained by age, illness duration, BMI and physical activity participation. CONCLUSIONS: The walking capacity and health-related muscular fitness are impaired in patients with schizophrenia and both should be a major focus in daily clinical practice and future research.
format Online
Article
Text
id pubmed-3553031
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-35530312013-01-28 An impaired health related muscular fitness contributes to a reduced walking capacity in patients with schizophrenia: a cross-sectional study Vancampfort, Davy Probst, Michel De Herdt, Amber Corredeira, Rui Manuel Nunes Carraro, Attilio De Wachter, Dirk De Hert, Marc BMC Psychiatry Research Article BACKGROUND: Patients with schizophrenia report muscle weakness. The relation of this muscle weakness with performing daily life activities such as walking is however not yet studied. The aim of this study was to quantify walking capacity and health related muscular fitness in patients with schizophrenia compared with age-, gender and body mass index (BMI)-matched healthy controls. Secondly, we identified variables that could explain the variability in walking capacity and in health related muscular fitness in patients with schizophrenia. METHODS: A total of 100 patients with schizophrenia and 40 healthy volunteers were initially screened. Eighty patients with schizophrenia (36.8±10.0 years) and the 40 age-, gender- and body mass index (BMI)-matched healthy volunteers (37.1±10.3 years) were finally included. All participants performed a standing broad jump test (SBJ) and a six-minute walk test (6MWT) and filled out the International Physical Activity Questionnaire. Patients additionally had a fasting metabolic laboratory screening and were assessed for psychiatric symptoms. RESULTS: Patients with schizophrenia did have lower 6MWT (17.9%, p<0.001) [effect size (ES)=−1.01] and SBJ (14.1%, p<0.001) (ES=−0.57) scores. Patients were also less physically active (1291.0±1201.8 metabolic equivalent-minutes/week versus 2463.1±1365.3, p<0.001) (ES=−0.91) than controls. Schizophrenia patients with metabolic syndrome (MetS) (35%) had a 23.9% lower (p<0.001) SBJ-score and 22.4% (p<0.001) lower 6MWT-score than those without MetS. In multiple regression analysis, 71.8% of the variance in 6MWT was explained by muscular fitness, BMI, presence of MetS and physical activity participation, while 53.9% of the variance in SBJ-score was explained by age, illness duration, BMI and physical activity participation. CONCLUSIONS: The walking capacity and health-related muscular fitness are impaired in patients with schizophrenia and both should be a major focus in daily clinical practice and future research. BioMed Central 2013-01-03 /pmc/articles/PMC3553031/ /pubmed/23286356 http://dx.doi.org/10.1186/1471-244X-13-5 Text en Copyright ©2013 Vancampfort et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vancampfort, Davy
Probst, Michel
De Herdt, Amber
Corredeira, Rui Manuel Nunes
Carraro, Attilio
De Wachter, Dirk
De Hert, Marc
An impaired health related muscular fitness contributes to a reduced walking capacity in patients with schizophrenia: a cross-sectional study
title An impaired health related muscular fitness contributes to a reduced walking capacity in patients with schizophrenia: a cross-sectional study
title_full An impaired health related muscular fitness contributes to a reduced walking capacity in patients with schizophrenia: a cross-sectional study
title_fullStr An impaired health related muscular fitness contributes to a reduced walking capacity in patients with schizophrenia: a cross-sectional study
title_full_unstemmed An impaired health related muscular fitness contributes to a reduced walking capacity in patients with schizophrenia: a cross-sectional study
title_short An impaired health related muscular fitness contributes to a reduced walking capacity in patients with schizophrenia: a cross-sectional study
title_sort impaired health related muscular fitness contributes to a reduced walking capacity in patients with schizophrenia: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553031/
https://www.ncbi.nlm.nih.gov/pubmed/23286356
http://dx.doi.org/10.1186/1471-244X-13-5
work_keys_str_mv AT vancampfortdavy animpairedhealthrelatedmuscularfitnesscontributestoareducedwalkingcapacityinpatientswithschizophreniaacrosssectionalstudy
AT probstmichel animpairedhealthrelatedmuscularfitnesscontributestoareducedwalkingcapacityinpatientswithschizophreniaacrosssectionalstudy
AT deherdtamber animpairedhealthrelatedmuscularfitnesscontributestoareducedwalkingcapacityinpatientswithschizophreniaacrosssectionalstudy
AT corredeiraruimanuelnunes animpairedhealthrelatedmuscularfitnesscontributestoareducedwalkingcapacityinpatientswithschizophreniaacrosssectionalstudy
AT carraroattilio animpairedhealthrelatedmuscularfitnesscontributestoareducedwalkingcapacityinpatientswithschizophreniaacrosssectionalstudy
AT dewachterdirk animpairedhealthrelatedmuscularfitnesscontributestoareducedwalkingcapacityinpatientswithschizophreniaacrosssectionalstudy
AT dehertmarc animpairedhealthrelatedmuscularfitnesscontributestoareducedwalkingcapacityinpatientswithschizophreniaacrosssectionalstudy
AT vancampfortdavy impairedhealthrelatedmuscularfitnesscontributestoareducedwalkingcapacityinpatientswithschizophreniaacrosssectionalstudy
AT probstmichel impairedhealthrelatedmuscularfitnesscontributestoareducedwalkingcapacityinpatientswithschizophreniaacrosssectionalstudy
AT deherdtamber impairedhealthrelatedmuscularfitnesscontributestoareducedwalkingcapacityinpatientswithschizophreniaacrosssectionalstudy
AT corredeiraruimanuelnunes impairedhealthrelatedmuscularfitnesscontributestoareducedwalkingcapacityinpatientswithschizophreniaacrosssectionalstudy
AT carraroattilio impairedhealthrelatedmuscularfitnesscontributestoareducedwalkingcapacityinpatientswithschizophreniaacrosssectionalstudy
AT dewachterdirk impairedhealthrelatedmuscularfitnesscontributestoareducedwalkingcapacityinpatientswithschizophreniaacrosssectionalstudy
AT dehertmarc impairedhealthrelatedmuscularfitnesscontributestoareducedwalkingcapacityinpatientswithschizophreniaacrosssectionalstudy