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Identification of a Small Molecule That Modifies MglA/SspA Interaction and Impairs Intramacrophage Survival of Francisella tularensis

The transcription factors MglA and SspA of Francisella tularensis form a heterodimer complex and interact with the RNA polymerase to regulate the expression of the Francisella pathogenicity island (FPI) genes. These genes are essential for this pathogen’s virulence and survival within host cells. In...

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Detalles Bibliográficos
Autores principales:	Wrench, Algevis P., Gardner, Christopher L., Gonzalez, Claudio F., Lorca, Graciela L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553074/ https://www.ncbi.nlm.nih.gov/pubmed/23372736 http://dx.doi.org/10.1371/journal.pone.0054498

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