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Genetic and Pharmacological Targeting of CSF-1/CSF-1R Inhibits Tumor-Associated Macrophages and Impairs BRAF-Induced Thyroid Cancer Progression
Advanced human thyroid cancers are densely infiltrated with tumor-associated macrophages (TAMs) and this correlates with a poor prognosis. We used BRAF-induced papillary thyroid cancer (PTC) mouse models to examine the role of TAMs in PTC progression. Following conditional activation of BRAF(V600E)...
Autores principales: | Ryder, Mabel, Gild, Matti, Hohl, Tobias M., Pamer, Eric, Knauf, Jeff, Ghossein, Ronald, Joyce, Johanna A., Fagin, James A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553126/ https://www.ncbi.nlm.nih.gov/pubmed/23372702 http://dx.doi.org/10.1371/journal.pone.0054302 |
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