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Development of a Physiologically Based Computational Kidney Model to Describe the Renal Excretion of Hydrophilic Agents in Rats

A physiologically based kidney model was developed to analyze the renal excretion and kidney exposure of hydrophilic agents, in particular contrast media, in rats. In order to study the influence of osmolality and viscosity changes, the model mechanistically represents urine concentration by water r...

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Detalles Bibliográficos
Autores principales:	Niederalt, Christoph, Wendl, Thomas, Kuepfer, Lars, Claassen, Karina, Loosen, Roland, Willmann, Stefan, Lippert, Joerg, Schultze-Mosgau, Marcus, Winkler, Julia, Burghaus, Rolf, Bräutigam, Matthias, Pietsch, Hubertus, Lengsfeld, Philipp
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553339/ https://www.ncbi.nlm.nih.gov/pubmed/23355822 http://dx.doi.org/10.3389/fphys.2012.00494

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