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Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved preclinical orthotopic and adjuvant therapy colon cancer models

OBJECTIVE: Advanced and recurrent diseases are the major causes of death in colon cancer. No standard preclinical model addresses advanced disease and spontaneous metastasis after orthotopic tumour growth. In this study, the authors report the establishment of such standardised orthotopic mouse mode...

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Detalles Bibliográficos
Autores principales:	Hackl, Christina, Man, Shan, Francia, Giulio, Milsom, Chloe, Xu, Ping, Kerbel, Robert S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Group 2013
Materias:	Colon
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553490/ https://www.ncbi.nlm.nih.gov/pubmed/22543158 http://dx.doi.org/10.1136/gutjnl-2011-301585

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