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Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up

BACKGROUND: Several environmental factors have been associated with increased risks for cervical cancer. We examined whether reproductive history, contraceptive use, or sexual behaviour increase the risk for cervical intraepithelial neoplasia grade 3 or worse (CIN3+) among women with persistent huma...

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Autores principales: Jensen, K E, Schmiedel, S, Norrild, B, Frederiksen, K, Iftner, T, Kjaer, S K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553518/
https://www.ncbi.nlm.nih.gov/pubmed/23169283
http://dx.doi.org/10.1038/bjc.2012.513
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author Jensen, K E
Schmiedel, S
Norrild, B
Frederiksen, K
Iftner, T
Kjaer, S K
author_facet Jensen, K E
Schmiedel, S
Norrild, B
Frederiksen, K
Iftner, T
Kjaer, S K
author_sort Jensen, K E
collection PubMed
description BACKGROUND: Several environmental factors have been associated with increased risks for cervical cancer. We examined whether reproductive history, contraceptive use, or sexual behaviour increase the risk for cervical intraepithelial neoplasia grade 3 or worse (CIN3+) among women with persistent human papillomavirus (HPV) infection. METHODS: A population-based cohort of women participated in a personal interview and underwent a gynaecological examination at which cervical specimens were obtained for HPV DNA testing. Follow-up information (∼13 years) on cervical lesions was obtained from the Danish Pathology Data Bank. Women who had a high-risk HPV infection comprised the overall study population (n=1353). A subgroup of women with persistent high-risk HPV infection (n=312) was identified. Hazard ratios (HRs) for a diagnosis of CIN3+ and the corresponding 95% confidence intervals (CIs) were calculated. RESULTS: Women with persistent HPV infection who had given birth had a significantly increased risk for CIN3+ (HR=1.78; 95% CI: 1.07–2.94). No association was found with pregnancy, use of intrauterine devices, or sexual behaviour. Based on small numbers, women with persistent HPV infection had a decreased risk for CIN3+ with any use of oral contraceptives (HR=0.54; 95% CI: 0.29–1.00). CONCLUSION: Childbirth increases the risk for subsequent CIN3+ among women with persistent HPV infection.
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spelling pubmed-35535182014-01-15 Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up Jensen, K E Schmiedel, S Norrild, B Frederiksen, K Iftner, T Kjaer, S K Br J Cancer Epidemiology BACKGROUND: Several environmental factors have been associated with increased risks for cervical cancer. We examined whether reproductive history, contraceptive use, or sexual behaviour increase the risk for cervical intraepithelial neoplasia grade 3 or worse (CIN3+) among women with persistent human papillomavirus (HPV) infection. METHODS: A population-based cohort of women participated in a personal interview and underwent a gynaecological examination at which cervical specimens were obtained for HPV DNA testing. Follow-up information (∼13 years) on cervical lesions was obtained from the Danish Pathology Data Bank. Women who had a high-risk HPV infection comprised the overall study population (n=1353). A subgroup of women with persistent high-risk HPV infection (n=312) was identified. Hazard ratios (HRs) for a diagnosis of CIN3+ and the corresponding 95% confidence intervals (CIs) were calculated. RESULTS: Women with persistent HPV infection who had given birth had a significantly increased risk for CIN3+ (HR=1.78; 95% CI: 1.07–2.94). No association was found with pregnancy, use of intrauterine devices, or sexual behaviour. Based on small numbers, women with persistent HPV infection had a decreased risk for CIN3+ with any use of oral contraceptives (HR=0.54; 95% CI: 0.29–1.00). CONCLUSION: Childbirth increases the risk for subsequent CIN3+ among women with persistent HPV infection. Nature Publishing Group 2013-01-15 2012-11-20 /pmc/articles/PMC3553518/ /pubmed/23169283 http://dx.doi.org/10.1038/bjc.2012.513 Text en Copyright © 2013 Cancer Research UK https://creativecommons.org/licenses/by-nc-sa/3.0/From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Epidemiology
Jensen, K E
Schmiedel, S
Norrild, B
Frederiksen, K
Iftner, T
Kjaer, S K
Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up
title Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up
title_full Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up
title_fullStr Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up
title_full_unstemmed Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up
title_short Parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up
title_sort parity as a cofactor for high-grade cervical disease among women with persistent human papillomavirus infection: a 13-year follow-up
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553518/
https://www.ncbi.nlm.nih.gov/pubmed/23169283
http://dx.doi.org/10.1038/bjc.2012.513
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