DNA damage-induced cytotoxicity is mediated by the cooperative interaction of phospho-NF-κB p50 and a single nucleotide in the κB-site

Phosphorylation of the NF-κB subunit, p50, is necessary for cytotoxicity in response to DNA methylation damage. Here, we demonstrate that serine 329 phosphorylation regulates the interaction of p50 with specific NF-κB binding elements based on the identity of a single κB-site nucleotide. Specificall...

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Detalles Bibliográficos
Autores principales: Crawley, Clayton D., Raleigh, David R., Kang, Shijun, Voce, David J., Schmitt, Adam M., Weichselbaum, Ralph R., Yamini, Bakhtiar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553961/
https://www.ncbi.nlm.nih.gov/pubmed/23180782
http://dx.doi.org/10.1093/nar/gks1120

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