Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques

The melanocortin-4 receptor (MC4R) is well recognized as an important mediator of body weight homeostasis. Activation of MC4R causes dramatic weight loss in rodent models, and mutations in human are associated with obesity. This makes MC4R a logical target for pharmacological therapy for the treatme...

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Autores principales: Kievit, Paul, Halem, Heather, Marks, Daniel L., Dong, Jesse Z., Glavas, Maria M., Sinnayah, Puspha, Pranger, Lindsay, Cowley, Michael A., Grove, Kevin L., Culler, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554387/
https://www.ncbi.nlm.nih.gov/pubmed/23048186
http://dx.doi.org/10.2337/db12-0598

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