A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation

BACKGROUND: Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF. FINDINGS: We included 178 young patients with lone AF and the first episode...

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Detalles Bibliográficos
Autores principales: Henningsen, Kristoffer M A, Olesen, Morten S, Sajadieh, Golnaz, Haunsoe, Stig, Svendsen, Jesper H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554423/
https://www.ncbi.nlm.nih.gov/pubmed/23279705
http://dx.doi.org/10.1186/1477-5751-12-1
Descripción
Sumario:BACKGROUND: Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF. FINDINGS: We included 178 young patients with lone AF and the first episode before the age of 40 years, and a control group of 875 healthy individuals. We analyzed a promoter SNP (−131CG) (rs4950928) in the Chitinase 3–like 1 (CHI3L1) gene encoding YKL-40, which had previously been associated with elevated levels of YKL-40. CONCLUSIONS: The (−131CG) genotype was not associated with increased risk of AF. Genetically increased YKL-40 levels were not associated to AF.

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