A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation

BACKGROUND: Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF. FINDINGS: We included 178 young patients with lone AF and the first episode...

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Autores principales: Henningsen, Kristoffer M A, Olesen, Morten S, Sajadieh, Golnaz, Haunsoe, Stig, Svendsen, Jesper H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554423/
https://www.ncbi.nlm.nih.gov/pubmed/23279705
http://dx.doi.org/10.1186/1477-5751-12-1
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author Henningsen, Kristoffer M A
Olesen, Morten S
Sajadieh, Golnaz
Haunsoe, Stig
Svendsen, Jesper H
author_facet Henningsen, Kristoffer M A
Olesen, Morten S
Sajadieh, Golnaz
Haunsoe, Stig
Svendsen, Jesper H
author_sort Henningsen, Kristoffer M A
collection PubMed
description BACKGROUND: Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF. FINDINGS: We included 178 young patients with lone AF and the first episode before the age of 40 years, and a control group of 875 healthy individuals. We analyzed a promoter SNP (−131CG) (rs4950928) in the Chitinase 3–like 1 (CHI3L1) gene encoding YKL-40, which had previously been associated with elevated levels of YKL-40. CONCLUSIONS: The (−131CG) genotype was not associated with increased risk of AF. Genetically increased YKL-40 levels were not associated to AF.
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spelling pubmed-35544232013-01-29 A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation Henningsen, Kristoffer M A Olesen, Morten S Sajadieh, Golnaz Haunsoe, Stig Svendsen, Jesper H J Negat Results Biomed Brief Report BACKGROUND: Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF. FINDINGS: We included 178 young patients with lone AF and the first episode before the age of 40 years, and a control group of 875 healthy individuals. We analyzed a promoter SNP (−131CG) (rs4950928) in the Chitinase 3–like 1 (CHI3L1) gene encoding YKL-40, which had previously been associated with elevated levels of YKL-40. CONCLUSIONS: The (−131CG) genotype was not associated with increased risk of AF. Genetically increased YKL-40 levels were not associated to AF. BioMed Central 2013-01-02 /pmc/articles/PMC3554423/ /pubmed/23279705 http://dx.doi.org/10.1186/1477-5751-12-1 Text en Copyright ©2013 Henningsen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Henningsen, Kristoffer M A
Olesen, Morten S
Sajadieh, Golnaz
Haunsoe, Stig
Svendsen, Jesper H
A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation
title A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation
title_full A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation
title_fullStr A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation
title_full_unstemmed A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation
title_short A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation
title_sort polymorphism associated with increased levels of ykl-40 and the risk of early onset of lone atrial fibrillation
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554423/
https://www.ncbi.nlm.nih.gov/pubmed/23279705
http://dx.doi.org/10.1186/1477-5751-12-1
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