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Immunogenomics for identification of disease resistance genes in pigs: a review focusing on Gram-negative bacilli

Over the past years, infectious disease has caused enormous economic loss in pig industry. Among the pathogens, gram negative bacteria not only cause inflammation, but also cause different diseases and make the pigs more susceptible to virus infection. Vaccination, medication and elimination of sick...

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Detalles Bibliográficos
Autores principales: Zhao, Shuhong, Zhu, Mengjin, Chen, Hongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554502/
https://www.ncbi.nlm.nih.gov/pubmed/23137309
http://dx.doi.org/10.1186/2049-1891-3-34
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author Zhao, Shuhong
Zhu, Mengjin
Chen, Hongbo
author_facet Zhao, Shuhong
Zhu, Mengjin
Chen, Hongbo
author_sort Zhao, Shuhong
collection PubMed
description Over the past years, infectious disease has caused enormous economic loss in pig industry. Among the pathogens, gram negative bacteria not only cause inflammation, but also cause different diseases and make the pigs more susceptible to virus infection. Vaccination, medication and elimination of sick pigs are major strategies of controlling disease. Genetic methods, such as selection of disease resistance in the pig, have not been widely used. Recently, the completion of the porcine whole genome sequencing has provided powerful tools to identify the genome regions that harboring genes controlling disease or immunity. Immunogenomics, which combines DNA variations, transcriptome, immune response, and QTL mapping data to illustrate the interactions between pathogen and host immune system, will be an effective genomics tool for identification of disease resistance genes in pigs. These genes will be potential targets for disease resistance in breeding programs. This paper reviewed the progress of disease resistance study in the pig focusing on Gram-negative bacilli. Major porcine Gram-negative bacilli and diseases, suggested candidate genes/pathways against porcine Gram-negative bacilli, and distributions of QTLs for immune capacity on pig chromosomes were summarized. Some tools for immunogenomics research were described. We conclude that integration of sequencing, whole genome associations, functional genomics studies, and immune response information is necessary to illustrate molecular mechanisms and key genes in disease resistance.
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spelling pubmed-35545022013-01-29 Immunogenomics for identification of disease resistance genes in pigs: a review focusing on Gram-negative bacilli Zhao, Shuhong Zhu, Mengjin Chen, Hongbo J Anim Sci Biotechnol Review Over the past years, infectious disease has caused enormous economic loss in pig industry. Among the pathogens, gram negative bacteria not only cause inflammation, but also cause different diseases and make the pigs more susceptible to virus infection. Vaccination, medication and elimination of sick pigs are major strategies of controlling disease. Genetic methods, such as selection of disease resistance in the pig, have not been widely used. Recently, the completion of the porcine whole genome sequencing has provided powerful tools to identify the genome regions that harboring genes controlling disease or immunity. Immunogenomics, which combines DNA variations, transcriptome, immune response, and QTL mapping data to illustrate the interactions between pathogen and host immune system, will be an effective genomics tool for identification of disease resistance genes in pigs. These genes will be potential targets for disease resistance in breeding programs. This paper reviewed the progress of disease resistance study in the pig focusing on Gram-negative bacilli. Major porcine Gram-negative bacilli and diseases, suggested candidate genes/pathways against porcine Gram-negative bacilli, and distributions of QTLs for immune capacity on pig chromosomes were summarized. Some tools for immunogenomics research were described. We conclude that integration of sequencing, whole genome associations, functional genomics studies, and immune response information is necessary to illustrate molecular mechanisms and key genes in disease resistance. BioMed Central 2012-11-08 /pmc/articles/PMC3554502/ /pubmed/23137309 http://dx.doi.org/10.1186/2049-1891-3-34 Text en Copyright ©2012 Zhao et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Zhao, Shuhong
Zhu, Mengjin
Chen, Hongbo
Immunogenomics for identification of disease resistance genes in pigs: a review focusing on Gram-negative bacilli
title Immunogenomics for identification of disease resistance genes in pigs: a review focusing on Gram-negative bacilli
title_full Immunogenomics for identification of disease resistance genes in pigs: a review focusing on Gram-negative bacilli
title_fullStr Immunogenomics for identification of disease resistance genes in pigs: a review focusing on Gram-negative bacilli
title_full_unstemmed Immunogenomics for identification of disease resistance genes in pigs: a review focusing on Gram-negative bacilli
title_short Immunogenomics for identification of disease resistance genes in pigs: a review focusing on Gram-negative bacilli
title_sort immunogenomics for identification of disease resistance genes in pigs: a review focusing on gram-negative bacilli
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554502/
https://www.ncbi.nlm.nih.gov/pubmed/23137309
http://dx.doi.org/10.1186/2049-1891-3-34
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