Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left–Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry

Failure to properly establish the left–right (L/R) axis is a major cause of congenital heart defects in humans, but how L/R patterning of the embryo leads to asymmetric cardiac morphogenesis is still unclear. We find that asymmetric Nodal signaling on the left and Bmp signaling act in parallel to es...

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Detalles Bibliográficos
Autores principales: Lenhart, Kari F., Holtzman, Nathalia G., Williams, Jessica R., Burdine, Rebecca D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554567/
https://www.ncbi.nlm.nih.gov/pubmed/23358434
http://dx.doi.org/10.1371/journal.pgen.1003109

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