Integrity and Regeneration of Mechanotransduction Machinery Regulate Aminoglycoside Entry and Sensory Cell Death

Sound perception requires functional hair cell mechanotransduction (MET) machinery, including the MET channels and tip-link proteins. Prior work showed that uptake of ototoxic aminoglycosides (AG) into hair cells requires functional MET channels. In this study, we examined whether tip-link proteins,...

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Detalles Bibliográficos
Autores principales: Vu, Andrew A., Nadaraja, Garani S., Huth, Markus E., Luk, Lauren, Kim, John, Chai, Renjie, Ricci, Anthony J., Cheng, Alan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554584/
https://www.ncbi.nlm.nih.gov/pubmed/23359017
http://dx.doi.org/10.1371/journal.pone.0054794

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