PIASγ Enhanced SUMO-2 Modification of Nurr1 Activation-Function-1 Domain Limits Nurr1 Transcriptional Synergy

Nurr1 (NR4A2) is a transcription factor that belongs to the orphan NR4A group of the nuclear receptor superfamily. Nurr1 plays key roles in the origin and maintenance of midbrain dopamine neurons, and peripheral inflammatory processes. PIASγ, a SUMO-E3 ligase, represses Nurr1 transcriptional activit...

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Detalles Bibliográficos
Autores principales: Arredondo, Cristian, Orellana, Marcelo, Vecchiola, Andrea, Pereira, Luis Alberto, Galdames, Leopoldo, Andrés, María Estela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554661/
https://www.ncbi.nlm.nih.gov/pubmed/23358114
http://dx.doi.org/10.1371/journal.pone.0055035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554661/
https://www.ncbi.nlm.nih.gov/pubmed/23358114
http://dx.doi.org/10.1371/journal.pone.0055035

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