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Conditional Knockout of Integrin α2β1 in Murine Megakaryocytes Leads to Reduced Mean Platelet Volume

We have engineered a transgenic mouse on a C57BL/6 background that bears a floxed Itga2 gene. The crossing of this mouse strain to transgenic mice expressing Cre recombinase driven by the megakaryocyte (MK)-specific Pf4 promoter permits the conditional knockout of Itga2 in the MK/platelet lineage. M...

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Detalles Bibliográficos
Autores principales:	Habart, David, Cheli, Yann, Nugent, Diane J., Ruggeri, Zaverio M., Kunicki, Thomas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554675/ https://www.ncbi.nlm.nih.gov/pubmed/23359821 http://dx.doi.org/10.1371/journal.pone.0055094

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