Computational Screening of the Human TF-Glycome Provides a Structural Definition for the Specificity of Anti-Tumor Antibody JAA-F11

Recombinant antibodies are of profound clinical significance; yet, anti-carbohydrate antibodies are prone to undesirable cross-reactivity with structurally related-glycans. Here we introduce a new technology called Computational Carbohydrate Grafting (CCG), which enables a virtual library of glycans...

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Detalles Bibliográficos
Autores principales: Tessier, Matthew B., Grant, Oliver C., Heimburg-Molinaro, Jamie, Smith, David, Jadey, Snehal, Gulick, Andrew M., Glushka, John, Deutscher, Susan L., Rittenhouse-Olson, Kate, Woods, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554700/
https://www.ncbi.nlm.nih.gov/pubmed/23365681
http://dx.doi.org/10.1371/journal.pone.0054874

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