FLT3 Mutations in Early T-Cell Precursor ALL Characterize a Stem Cell Like Leukemia and Imply the Clinical Use of Tyrosine Kinase Inhibitors

Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) has been identified as high-risk subgroup of acute T-lymphoblastic leukemia (T-ALL) with a high rate of FLT3-mutations in adults. To unravel the underlying pathomechanisms and the clinical course we assessed molecular alterations and clin...

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Detalles Bibliográficos
Autores principales: Neumann, Martin, Coskun, Ebru, Fransecky, Lars, Mochmann, Liliana H., Bartram, Isabelle, Farhadi Sartangi, Nasrin, Heesch, Sandra, Gökbuget, Nicola, Schwartz, Stefan, Brandts, Christian, Schlee, Cornelia, Haas, Rainer, Dührsen, Ulrich, Griesshammer, Martin, Döhner, Hartmut, Ehninger, Gerhard, Burmeister, Thomas, Blau, Olga, Thiel, Eckhard, Hoelzer, Dieter, Hofmann, Wolf-Karsten, Baldus, Claudia D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554732/
https://www.ncbi.nlm.nih.gov/pubmed/23359050
http://dx.doi.org/10.1371/journal.pone.0053190

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