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High Frequency Targeted Mutagenesis Using Engineered Endonucleases and DNA-End Processing Enzymes

Targeting DNA double-strand breaks is a powerful strategy for gene inactivation applications. Without the use of a repair plasmid, targeted mutagenesis can be achieved through Non-Homologous End joining (NHEJ) pathways. However, many of the DNA breaks produced by engineered nucleases may be subject...

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Detalles Bibliográficos
Autores principales:	Delacôte, Fabien, Perez, Christophe, Guyot, Valérie, Duhamel, Marianne, Rochon, Christelle, Ollivier, Nathalie, Macmaster, Rachel, Silva, George H., Pâques, Frédéric, Daboussi, Fayza, Duchateau, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554739/ https://www.ncbi.nlm.nih.gov/pubmed/23359797 http://dx.doi.org/10.1371/journal.pone.0053217

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