Cargando…

Molecular Determinants of Epidermal Growth Factor Binding: A Molecular Dynamics Study

The epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinase family that plays a role in multiple cellular processes. Activation of EGFR requires binding of a ligand on the extracellular domain to promote conformational changes leading to dimerization and transphosphorylat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sanders, Jeffrey M., Wampole, Matthew E., Thakur, Mathew L., Wickstrom, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554757/ https://www.ncbi.nlm.nih.gov/pubmed/23382875 http://dx.doi.org/10.1371/journal.pone.0054136

Ejemplares similares

Consistent Surgeon Evaluations of Three-Dimensional Rendering of PET/CT Scans of the Abdomen of a Patient with a Ductal Pancreatic Mass
por: Wampole, Matthew E., et al.
Publicado: (2013)

Fluorescence Detection of KRAS2 mRNA Hybridization in Lung Cancer Cells with PNA-Peptides Containing an Internal Thiazole Orange
por: Sonar, Mahesh V., et al.
Publicado: (2014)

Molecular Dynamics Analysis of Binding Sites of Epidermal Growth Factor Receptor Kinase Inhibitors
por: Li, Dong-Dong, et al.
Publicado: (2020)

Molecular Determinants of Glioblastoma Response to Epidermal Growth Factor Receptor Kinase Inhibitors
por: Komotar, Ricardo J., et al.
Publicado: (2008)

Computational modeling reveals molecular details of epidermal growth factor binding
por: Mayawala, Kapil, et al.
Publicado: (2005)

Molecular determination of epidermal growth factor receptor in normal and neoplastic colorectal mucosa
por: Piazzi, G, et al.
Publicado: (2006)

Molecular dynamic simulation reveals the molecular interactions of epidermal growth factor receptor with musk xylene are involved in the carcinogenicity
por: Fei, Huaxing, et al.
Publicado: (2023)

A Gαi–GIV Molecular Complex Binds Epidermal Growth Factor Receptor and Determines Whether Cells Migrate or Proliferate
por: Ghosh, Pradipta, et al.
Publicado: (2010)

Ligand binding and dynamics of the monomeric epidermal growth factor receptor ectodomain
por: Loeffler, Hannes H, et al.
Publicado: (2013)

Molecular Mechanisms that Regulate Epidermal Growth Factor Receptor Inactivation
por: Ceresa, Brian P., et al.
Publicado: (2008)

Molecular basis for multimerization in the activation of the epidermal growth factor receptor
por: Huang, Yongjian, et al.
Publicado: (2016)

Biological Evaluation and Molecular Dynamics Simulation of Chalcone Derivatives as Epidermal Growth Factor-Tyrosine Kinase Inhibitors
por: Sangpheak, Kanyani, et al.
Publicado: (2019)

Molecular Targeting of Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor (VEGFR)
por: Kaufman, Nichole E. M., et al.
Publicado: (2021)

Molecular-Targeted Therapies for Epidermal Growth Factor Receptor and Its Resistance Mechanisms
por: Yamaoka, Toshimitsu, et al.
Publicado: (2017)

Molecular mechanisms of resistance in epidermal growth factor receptor-mutant lung adenocarcinomas
por: Cortot, Alexis B., et al.
Publicado: (2014)

Molecular Docking and Simulation-Binding Analysis of Plant Phytochemicals with the Hepatocellular Carcinoma Targets Epidermal Growth Factor Receptor and Caspase-9
por: Mustafa, Ghulam, et al.
Publicado: (2023)

Conformational Transition Pathways of Epidermal Growth Factor Receptor Kinase Domain from Multiple Molecular Dynamics Simulations and Bayesian Clustering
por: Li, Yan, et al.
Publicado: (2014)

Identification of Dual-Target Inhibitors for Epidermal Growth Factor Receptor and AKT: Virtual Screening Based on Structure and Molecular Dynamics Study
por: Yang, Hanyu, et al.
Publicado: (2023)

Determinants of Orexin Receptor Binding and Activation—A Molecular Dynamics Study
por: Karhu, Lasse, et al.
Publicado: (2019)

Structural and Dynamic Determinants of Molecular Recognition in Bile Acid-Binding Proteins
por: Toke, Orsolya
Publicado: (2022)

Dynamical Rearrangement of Human Epidermal Growth Factor Receptor 2 upon Antibody Binding: Effects on the Dimerization
por: R. Magalhães, Pedro, et al.
Publicado: (2019)

Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice
por: Huang, Guangcun, et al.
Publicado: (2012)

Molecular Imaging of Hepatocellular Carcinoma Xenografts with Epidermal Growth Factor Receptor Targeted Affibody Probes
por: Zhao, Ping, et al.
Publicado: (2013)

A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor
por: Huang, Yongjian, et al.
Publicado: (2021)

Molecular determinants of drug-specific sensitivity for epidermal growth factor receptor (EGFR) exon 19 and 20 mutants in non-small cell lung cancer
por: Tsigelny, Igor F., et al.
Publicado: (2015)

Molecular Dynamic Simulations Reveal the Structural Determinants of Fatty Acid Binding to Oxy-Myoglobin
por: Chintapalli, Sree V., et al.
Publicado: (2015)

Functional and Molecular Characterization of C91S Mutation in the Second Epidermal Growth Factor-Like Domain of Factor VII
por: Mashayekhi, Amir, et al.
Publicado: (2018)

Molecular imaging of a fluorescent antibody against epidermal growth factor receptor detects high-grade glioma
por: Zhou, Quan, et al.
Publicado: (2021)

Clinical significance of heparin-binding epidermal growth factor-like growth factor in peritoneal fluid of ovarian cancer
por: Yagi, H, et al.
Publicado: (2005)

Characterization of a Drosophila protein that binds both epidermal growth factor and insulin-related growth factors
Publicado: (1987)

Fibrogenic Effects of Heparin-Binding Epidermal Growth Factor-like Growth Factor: Myeloid or Epithelial Origin?
por: Martin, James G., et al.
Publicado: (2022)

Efficacy of epidermal growth factor receptor-targeted molecular therapy in anaplastic thyroid cancer cell lines
por: Nobuhara, Y, et al.
Publicado: (2005)

Molecular Alterations in Epidermal Growth Factor Receptors as Potential Predictors of Invasion in Complete Hydatidiform Moles (CHM)
por: Jacob, Jemima, et al.
Publicado: (2012)

Interactions of ABCG2 (BCRP) with epidermal growth factor receptor kinase inhibitors developed for molecular imaging
por: Qawasmi, Israa, et al.
Publicado: (2014)

Transforming growth factor alpha and epidermal growth factor levels in bladder cancer and their relationship to epidermal growth factor receptor.
por: Mellon, J. K., et al.
Publicado: (1996)

Harnessing Integrative Omics to Facilitate Molecular Imaging of the Human Epidermal Growth Factor Receptor Family for Precision Medicine
por: Pool, Martin, et al.
Publicado: (2017)

Epidermal growth factor receptor in ovarian tumours: correlation of immunohistochemistry with ligand binding assay.
por: Henzen-Logmans, S. C., et al.
Publicado: (1992)

Epidermal growth factor receptor mRNA expression: A potential molecular escape mechanism from regorafenib
por: Matsusaka, Satoshi, et al.
Publicado: (2020)

Enhancement of epidermal regeneration by biosynthetic epidermal growth factor
Publicado: (1986)

Molecular dynamics simulation analysis of the effect of T790M mutation on epidermal growth factor receptor protein architecture in non-small cell lung carcinoma
por: Peng, Xiao-Nu, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3uce68dv2o0u5mqg0fja013gim