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A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene
Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like p...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554877/ https://www.ncbi.nlm.nih.gov/pubmed/22105620 http://dx.doi.org/10.1038/mp.2011.148 |
| _version_ | 1782256979422478336 |
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| author | Papassotiropoulos, A Stefanova, E Vogler, C Gschwind, L Ackermann, S Spalek, K Rasch, B Heck, A Aerni, A Hanser, E Demougin, P Huynh, K-D Luechinger, R Klarhöfer, M Novakovic, I Kostic, V Boesiger, P Scheffler, K de Quervain, D J-F |
| author_facet | Papassotiropoulos, A Stefanova, E Vogler, C Gschwind, L Ackermann, S Spalek, K Rasch, B Heck, A Aerni, A Hanser, E Demougin, P Huynh, K-D Luechinger, R Klarhöfer, M Novakovic, I Kostic, V Boesiger, P Scheffler, K de Quervain, D J-F |
| author_sort | Papassotiropoulos, A |
| collection | PubMed |
| description | Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) was significantly (P=7 × 10(−8)) associated with verbal memory performance in a cognitively healthy cohort from Switzerland (n=1073) and was replicated in a second cohort from Serbia (n=524; P=0.003). Gene expression studies showed CTNNBL1 genotype-dependent differences in beta-catenin-like protein 1 mRNA levels in the human cortex. Functional magnetic resonance imaging in 322 subjects detected CTNNBL1 genotype-dependent differences in memory-related brain activations. Converging evidence from independent experiments and different methodological approaches suggests a role for CTNNBL1 in human memory. |
| format | Online Article Text |
| id | pubmed-3554877 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-35548772013-01-25 A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene Papassotiropoulos, A Stefanova, E Vogler, C Gschwind, L Ackermann, S Spalek, K Rasch, B Heck, A Aerni, A Hanser, E Demougin, P Huynh, K-D Luechinger, R Klarhöfer, M Novakovic, I Kostic, V Boesiger, P Scheffler, K de Quervain, D J-F Mol Psychiatry Original Article Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) was significantly (P=7 × 10(−8)) associated with verbal memory performance in a cognitively healthy cohort from Switzerland (n=1073) and was replicated in a second cohort from Serbia (n=524; P=0.003). Gene expression studies showed CTNNBL1 genotype-dependent differences in beta-catenin-like protein 1 mRNA levels in the human cortex. Functional magnetic resonance imaging in 322 subjects detected CTNNBL1 genotype-dependent differences in memory-related brain activations. Converging evidence from independent experiments and different methodological approaches suggests a role for CTNNBL1 in human memory. Nature Publishing Group 2013-02 2011-11-22 /pmc/articles/PMC3554877/ /pubmed/22105620 http://dx.doi.org/10.1038/mp.2011.148 Text en Copyright © 2013 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
| spellingShingle | Original Article Papassotiropoulos, A Stefanova, E Vogler, C Gschwind, L Ackermann, S Spalek, K Rasch, B Heck, A Aerni, A Hanser, E Demougin, P Huynh, K-D Luechinger, R Klarhöfer, M Novakovic, I Kostic, V Boesiger, P Scheffler, K de Quervain, D J-F A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene |
| title | A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene |
| title_full | A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene |
| title_fullStr | A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene |
| title_full_unstemmed | A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene |
| title_short | A genome-wide survey and functional brain imaging study identify CTNNBL1 as a memory-related gene |
| title_sort | genome-wide survey and functional brain imaging study identify ctnnbl1 as a memory-related gene |
| topic | Original Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554877/ https://www.ncbi.nlm.nih.gov/pubmed/22105620 http://dx.doi.org/10.1038/mp.2011.148 |
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