Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset

Lectin-like ox-LDL receptors (LOX-1) play a crucial role in the ox-LDL–induced pathological transformation of vessel-wall components, a crucial early step in atherogenesis. LOX-1 dynamics is quantitatively investigated in human endothelial cells (HUVECs) exposed to environmental nanotopographies. We...

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Detalles Bibliográficos
Autores principales: Di Rienzo, Carmine, Jacchetti, Emanuela, Cardarelli, Francesco, Bizzarri, Ranieri, Beltram, Fabio, Cecchini, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555090/
https://www.ncbi.nlm.nih.gov/pubmed/23355954
http://dx.doi.org/10.1038/srep01141
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author Di Rienzo, Carmine
Jacchetti, Emanuela
Cardarelli, Francesco
Bizzarri, Ranieri
Beltram, Fabio
Cecchini, Marco
author_facet Di Rienzo, Carmine
Jacchetti, Emanuela
Cardarelli, Francesco
Bizzarri, Ranieri
Beltram, Fabio
Cecchini, Marco
author_sort Di Rienzo, Carmine
collection PubMed
description Lectin-like ox-LDL receptors (LOX-1) play a crucial role in the ox-LDL–induced pathological transformation of vessel-wall components, a crucial early step in atherogenesis. LOX-1 dynamics is quantitatively investigated in human endothelial cells (HUVECs) exposed to environmental nanotopographies. We demonstrate distinct nanotopography-induced cell phenotypes, characterized by different morphology, LOX-1 diffusivity and oligomerization state: HUVECs on flat surfaces exhibit the behavior found in pro-atherogenic conditions, while growth on nanogratings can interfere with LOX-1 dynamics and lead to a behavior characteristic of normal, non-pathological conditions.
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spelling pubmed-35550902013-01-25 Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset Di Rienzo, Carmine Jacchetti, Emanuela Cardarelli, Francesco Bizzarri, Ranieri Beltram, Fabio Cecchini, Marco Sci Rep Article Lectin-like ox-LDL receptors (LOX-1) play a crucial role in the ox-LDL–induced pathological transformation of vessel-wall components, a crucial early step in atherogenesis. LOX-1 dynamics is quantitatively investigated in human endothelial cells (HUVECs) exposed to environmental nanotopographies. We demonstrate distinct nanotopography-induced cell phenotypes, characterized by different morphology, LOX-1 diffusivity and oligomerization state: HUVECs on flat surfaces exhibit the behavior found in pro-atherogenic conditions, while growth on nanogratings can interfere with LOX-1 dynamics and lead to a behavior characteristic of normal, non-pathological conditions. Nature Publishing Group 2013-01-25 /pmc/articles/PMC3555090/ /pubmed/23355954 http://dx.doi.org/10.1038/srep01141 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Di Rienzo, Carmine
Jacchetti, Emanuela
Cardarelli, Francesco
Bizzarri, Ranieri
Beltram, Fabio
Cecchini, Marco
Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset
title Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset
title_full Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset
title_fullStr Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset
title_full_unstemmed Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset
title_short Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset
title_sort unveiling lox-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555090/
https://www.ncbi.nlm.nih.gov/pubmed/23355954
http://dx.doi.org/10.1038/srep01141
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