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Endothelin-1 as a mediator and potential biomarker for interferon induced pulmonary toxicity

Endothelin-1 is a potent vasoconstrictor and a therapeutic target in pulmonary arterial hypertension. Endothelial cells are the physiological source of endothelin-1 but in vitro data from our group shows that interferons (IFNα, IFNβ or IFNγ) induce endothelin-1 in pulmonary vascular smooth muscle ce...

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Detalles Bibliográficos
Autores principales:	George, Peter M., Cunningham, Morven E., Galloway-Phillipps, Neil, Badiger, Rekha, Alazawi, William, Foster, Graham R., Mitchell, Jane A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2012
Materias:	Special Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555421/ https://www.ncbi.nlm.nih.gov/pubmed/23372935 http://dx.doi.org/10.4103/2045-8932.105039

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