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Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 diabetes; a randomized double-blind clinical trial
BACKGROUND & THE PURPOSE OF THE STUDY: Prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. To reduce its risk and progression, preventive strategies are needed. Vitamin supplementation such as vitamin D is one of the strategies. This study was designed to investigate the effec...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555787/ https://www.ncbi.nlm.nih.gov/pubmed/23351271 http://dx.doi.org/10.1186/2008-2231-20-10 |
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author | Heshmat, Ramin Tabatabaei-Malazy, Ozra Abbaszadeh-Ahranjani, Shabnam Shahbazi, Samimeh Khooshehchin, Ghazal Bandarian, Fathemeh Larijani, Bagher |
author_facet | Heshmat, Ramin Tabatabaei-Malazy, Ozra Abbaszadeh-Ahranjani, Shabnam Shahbazi, Samimeh Khooshehchin, Ghazal Bandarian, Fathemeh Larijani, Bagher |
author_sort | Heshmat, Ramin |
collection | PubMed |
description | BACKGROUND & THE PURPOSE OF THE STUDY: Prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. To reduce its risk and progression, preventive strategies are needed. Vitamin supplementation such as vitamin D is one of the strategies. This study was designed to investigate the effect of injection of vitamin D on insulin resistance and anthropometric parameters in T2DM. METHODS: This randomized double-blind clinical trial was conducted with 42 diabetic patients in two groups; intervention group with single intramuscular injection of 300,000 International Unit (IU) of vitamin D3 and the placebo group. After recording demographic and anthropometric factors (waist circumference, blood pressure and body mass index), fasting blood samples was taken for measurement of blood glucose, 25-hydroxyvitamin D3 (25-OHD3), insulin, glycosylated hemoglobin A1c (HbA1c) and estimation of Homeostasis Model Assessment Index (HOMA) in two times; before study and after three months. RESULTS: Two groups had similar baseline characteristics (each group = 21 subjects). Three months after vitamin D injection, HbA1c, anthropometric factors and HOMA index in intervention group stayed constant, however, serum 25- OHD3 was significantly increased (p = 0.007). CONCLUSION: The present data is not convincing and further studies with large sample sizes are needed to show the definite effect of injection of vitamin D on control of diabetes and its risk. |
format | Online Article Text |
id | pubmed-3555787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35557872013-01-31 Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 diabetes; a randomized double-blind clinical trial Heshmat, Ramin Tabatabaei-Malazy, Ozra Abbaszadeh-Ahranjani, Shabnam Shahbazi, Samimeh Khooshehchin, Ghazal Bandarian, Fathemeh Larijani, Bagher Daru Research Article BACKGROUND & THE PURPOSE OF THE STUDY: Prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. To reduce its risk and progression, preventive strategies are needed. Vitamin supplementation such as vitamin D is one of the strategies. This study was designed to investigate the effect of injection of vitamin D on insulin resistance and anthropometric parameters in T2DM. METHODS: This randomized double-blind clinical trial was conducted with 42 diabetic patients in two groups; intervention group with single intramuscular injection of 300,000 International Unit (IU) of vitamin D3 and the placebo group. After recording demographic and anthropometric factors (waist circumference, blood pressure and body mass index), fasting blood samples was taken for measurement of blood glucose, 25-hydroxyvitamin D3 (25-OHD3), insulin, glycosylated hemoglobin A1c (HbA1c) and estimation of Homeostasis Model Assessment Index (HOMA) in two times; before study and after three months. RESULTS: Two groups had similar baseline characteristics (each group = 21 subjects). Three months after vitamin D injection, HbA1c, anthropometric factors and HOMA index in intervention group stayed constant, however, serum 25- OHD3 was significantly increased (p = 0.007). CONCLUSION: The present data is not convincing and further studies with large sample sizes are needed to show the definite effect of injection of vitamin D on control of diabetes and its risk. BioMed Central 2012-08-28 /pmc/articles/PMC3555787/ /pubmed/23351271 http://dx.doi.org/10.1186/2008-2231-20-10 Text en Copyright ©2012 Elangovan et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Heshmat, Ramin Tabatabaei-Malazy, Ozra Abbaszadeh-Ahranjani, Shabnam Shahbazi, Samimeh Khooshehchin, Ghazal Bandarian, Fathemeh Larijani, Bagher Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 diabetes; a randomized double-blind clinical trial |
title | Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 diabetes; a randomized double-blind clinical trial |
title_full | Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 diabetes; a randomized double-blind clinical trial |
title_fullStr | Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 diabetes; a randomized double-blind clinical trial |
title_full_unstemmed | Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 diabetes; a randomized double-blind clinical trial |
title_short | Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 diabetes; a randomized double-blind clinical trial |
title_sort | effect of vitamin d on insulin resistance and anthropometric parameters in type 2 diabetes; a randomized double-blind clinical trial |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555787/ https://www.ncbi.nlm.nih.gov/pubmed/23351271 http://dx.doi.org/10.1186/2008-2231-20-10 |
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