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Common Variation Neighbouring Micro-RNA 22 Is Associated with Increased Left Ventricular Mass
AIMS: Previous genome-wide linkage analysis has suggested that chromosomal region 17p13.3 may harbour genes influencing left ventricular mass (LVM) in man. To date, the genetic factors accounting for LVM variability remain largely unknown but a non-coding RNA gene within this region, micro-RNA 22 (m...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555935/ https://www.ncbi.nlm.nih.gov/pubmed/23372812 http://dx.doi.org/10.1371/journal.pone.0055061 |
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author | Harper, Andrew R. Mayosi, Bongani M. Rodriguez, Antony Rahman, Thahira Hall, Darroch Mamasoula, Chrysovalanto Avery, Peter J. Keavney, Bernard D. |
author_facet | Harper, Andrew R. Mayosi, Bongani M. Rodriguez, Antony Rahman, Thahira Hall, Darroch Mamasoula, Chrysovalanto Avery, Peter J. Keavney, Bernard D. |
author_sort | Harper, Andrew R. |
collection | PubMed |
description | AIMS: Previous genome-wide linkage analysis has suggested that chromosomal region 17p13.3 may harbour genes influencing left ventricular mass (LVM) in man. To date, the genetic factors accounting for LVM variability remain largely unknown but a non-coding RNA gene within this region, micro-RNA 22 (miR-22), has been implicated in cardiac hypertrophy and heart failure in animal models. We thus investigated the relationship between common genetic polymorphisms surrounding miR-22 and left ventricular mass in a family-based association study. METHODS AND RESULTS: We studied a cohort of 255 families comprising 1,425 individuals ascertained via a hypertensive proband. Ten single nucleotide polymorphisms which together tagged common genetic variation surrounding the miR-22 gene were genotyped. There was evidence of association between the rs7223247 polymorphism, which lies within the 3′UTR of a gene of unknown function, TLCD2, immediately downstream from miR-22, and left ventricular mass determined by Sokolow-Lyon voltage (Bonferroni corrected p-value = 0.038). The T allele at rs7223247 was associated with an 0.272 standard deviation higher Sokolow-Lyon voltage. Genotype was responsible for ∼1% of the population variability in LVM. CONCLUSIONS: Genotype at the rs7223247 polymorphism affects left ventricular mass determined by Sokolow-Lyon voltage. The neighbouring genes miR-22 and TLCD2 are strong candidates to account for this observation. |
format | Online Article Text |
id | pubmed-3555935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35559352013-01-31 Common Variation Neighbouring Micro-RNA 22 Is Associated with Increased Left Ventricular Mass Harper, Andrew R. Mayosi, Bongani M. Rodriguez, Antony Rahman, Thahira Hall, Darroch Mamasoula, Chrysovalanto Avery, Peter J. Keavney, Bernard D. PLoS One Research Article AIMS: Previous genome-wide linkage analysis has suggested that chromosomal region 17p13.3 may harbour genes influencing left ventricular mass (LVM) in man. To date, the genetic factors accounting for LVM variability remain largely unknown but a non-coding RNA gene within this region, micro-RNA 22 (miR-22), has been implicated in cardiac hypertrophy and heart failure in animal models. We thus investigated the relationship between common genetic polymorphisms surrounding miR-22 and left ventricular mass in a family-based association study. METHODS AND RESULTS: We studied a cohort of 255 families comprising 1,425 individuals ascertained via a hypertensive proband. Ten single nucleotide polymorphisms which together tagged common genetic variation surrounding the miR-22 gene were genotyped. There was evidence of association between the rs7223247 polymorphism, which lies within the 3′UTR of a gene of unknown function, TLCD2, immediately downstream from miR-22, and left ventricular mass determined by Sokolow-Lyon voltage (Bonferroni corrected p-value = 0.038). The T allele at rs7223247 was associated with an 0.272 standard deviation higher Sokolow-Lyon voltage. Genotype was responsible for ∼1% of the population variability in LVM. CONCLUSIONS: Genotype at the rs7223247 polymorphism affects left ventricular mass determined by Sokolow-Lyon voltage. The neighbouring genes miR-22 and TLCD2 are strong candidates to account for this observation. Public Library of Science 2013-01-25 /pmc/articles/PMC3555935/ /pubmed/23372812 http://dx.doi.org/10.1371/journal.pone.0055061 Text en © 2013 Harper et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Harper, Andrew R. Mayosi, Bongani M. Rodriguez, Antony Rahman, Thahira Hall, Darroch Mamasoula, Chrysovalanto Avery, Peter J. Keavney, Bernard D. Common Variation Neighbouring Micro-RNA 22 Is Associated with Increased Left Ventricular Mass |
title | Common Variation Neighbouring Micro-RNA 22 Is Associated with Increased Left Ventricular Mass |
title_full | Common Variation Neighbouring Micro-RNA 22 Is Associated with Increased Left Ventricular Mass |
title_fullStr | Common Variation Neighbouring Micro-RNA 22 Is Associated with Increased Left Ventricular Mass |
title_full_unstemmed | Common Variation Neighbouring Micro-RNA 22 Is Associated with Increased Left Ventricular Mass |
title_short | Common Variation Neighbouring Micro-RNA 22 Is Associated with Increased Left Ventricular Mass |
title_sort | common variation neighbouring micro-rna 22 is associated with increased left ventricular mass |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555935/ https://www.ncbi.nlm.nih.gov/pubmed/23372812 http://dx.doi.org/10.1371/journal.pone.0055061 |
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