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Cell-Based Small-Molecule Compound Screen Identifies Fenretinide as Potential Therapeutic for Translocation-Positive Rhabdomyosarcoma

A subset of paediatric sarcomas are characterized by chromosomal translocations encoding specific oncogenic transcription factors. Such fusion proteins represent tumor specific therapeutic targets although so far it has not been possible to directly inhibit their activity by small-molecule compounds...

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Detalles Bibliográficos
Autores principales: Herrero Martín, David, Boro, Aleksandar, Schäfer, Beat W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555977/
https://www.ncbi.nlm.nih.gov/pubmed/23372815
http://dx.doi.org/10.1371/journal.pone.0055072

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