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Generation of Biologically Active Multi-Sialylated Recombinant Human EPOFc in Plants

Hyperglycosylated proteins are more stable, show increased serum half-life and less sensitivity to proteolysis compared to non-sialylated forms. This applies particularly to recombinant human erythropoietin (rhEPO). Recent progress in N-glycoengineering of non-mammalian expression hosts resulted in...

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Detalles Bibliográficos
Autores principales:	Castilho, Alexandra, Neumann, Laura, Gattinger, Pia, Strasser, Richard, Vorauer-Uhl, Karola, Sterovsky, Thomas, Altmann, Friedrich, Steinkellner, Herta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555983/ https://www.ncbi.nlm.nih.gov/pubmed/23372778 http://dx.doi.org/10.1371/journal.pone.0054836

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